Immunohistochemical Demonstration of COX2 in Various Lesions of Oral Cavity: Immunohistochemical Expression of COX-2 in Oral Lesions

Salman Zafar; Nazia Qamar; Hurtamina Khan; Madeeha Shahid; Sadia Sundus; Farah Malik

doi:10.54393/pjhs.v6i2.2045

Authors

Salman Zafar Department of Pathology, Fazaia Ruth Pfau Medical College, Karachi, Pakistan
Nazia Qamar Department of Pathology, Fazaia Ruth Pfau Medical College, Karachi, Pakistan
Hurtamina Khan Department of Ear, Nose and Throat, Jinnah Sindh Medical University, Jinnah Postgraduate Medical Centre, Karachi, Pakistan
Madeeha Shahid Department of Surgery, Fazaia Ruth Pfau Medical College, Karachi, Pakistan
Sadia Sundus Department of Anatomy, Liaquat College of Medicine and Dentistry, Karachi, Pakistan
Farah Malik Department of Anatomy, Liaquat College of Medicine and Dentistry, Karachi, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i2.2045

Keywords:

Cyclooxygenase-2, Immunohistochemistry, Oral Lesions, Oral Squamous Cell Carcinoma, Precancerous Lesions

Abstract

Cyclooxygenase enzyme facilitates the conversion of arachidonic acid into pro-inflammatory compounds, resulting in formation of prostaglandins, which contributes substantially to the carcinogenic process. Objective: To analyze the immunohistochemical COX2 enzyme expression in various lesion of oral cavity. Methods: A total of 60 formalin fixed, paraffinized blocks (including 10 healthy oral mucosa cases, 10 cases of leukoplakia. 10 cases of oral sub mucosal fibrosis, 10 cases of dysplasia, 10 cases of well differentiated carcinoma, 10 cases of highly aggressive invasive squamous carcinoma) were randomly selected during the period of Jan, 2022 till Dec, 2023. Immunohistochemistry was done on each case for analyzing COX2 expression. Data was statistically analyzed by using chi square test. P value < 0.05 was taken as substantial. Result: It was found that the expression level was high in invasive carcinoma as compared with other oral lesion. Conclusion: Present study strongly supported the involvement of COX2 in the advancement of precancerous lesions of oral cavity to malignant one.

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