Prevalence and Predictors of Non-Compliance with Pharmacological Treatment in Diabetes
Non-Compliance with Pharmacological Treatment in Diabetes
DOI:
https://doi.org/10.54393/pjhs.v4i10.1089Keywords:
Diabetes Mellitus (DM), Non-Adherence, Pharmacological TherapyAbstract
Although the incidence of failure to comply to prescribe drugs is very varied, it may be the most frequent cause of suboptimal treatment results in diabetic patients. In the research region, there are little data on the extent of non-adherence to medicines and related causes. Objective: To determine the prevalence of non-adherence to medications in patients with diabetes and the factors leading to such practices. Methods: A descriptive study designed was chosen to evaluate 191 patients with diabetes enrolled at the department of medicine, combined military hospital, Nowshera, during the period May 2022 to May 2023. Non-adherence was confirmed clinically by taking history and biochemically by poor glycemic profile. SPSS version 24 was used to analyze the data. Results: The age of the patients ranged from 18 to 60 years. The mean age of the patients was 36.17 years with standard deviation 7.53. Age group 18 to 40 years comprised of 113 (59.2%) participants. The male participants were 129 (67.5%) in number. Non-adherence was observed in 86(45.5%) patients. Factors leading to non-adherence included financial constraints 32(37.2%), medications related to complications 16(18.6%). Conclusions: Diabetes patients often fail to comply with their prescribed prescriptions in the study region. To reduce disengagement among diabetes patients, public health programs should be reinforced.
References
Mann DM, Ponieman D, Leventhal H, Halm EA. Predictors of adherence to diabetes medications: the role of disease and medication beliefs. Journal of Behavioral Medicine. 2009 Jun; 32: 278-84. doi: 10.1007/s10865-009-9202-y. DOI: https://doi.org/10.1007/s10865-009-9202-y
Nuche-Berenguer B and Kupfer LE. Readiness of sub-Saharan Africa healthcare systems for the new pandemic, diabetes: a systematic review. Journal of Diabetes Research. 2018 Feb; 2018: 9262395. doi: 10.1155/2018/9262395. DOI: https://doi.org/10.1155/2018/9262395
Jufar AH, Jima Z, Gemeda D. Prevalence and factors contributing to non-adherence to diabetes treatment among diabetic patients attending government hospitals in Addis Ababa. International Journal of Tropical Disease & Health. 2018 Oct; 32(3): 1-1. doi: 10.9734/IJTDH/2018/43867. DOI: https://doi.org/10.9734/IJTDH/2018/43867
Lee WC, Balu S, Cobden D, Joshi AV, Pashos CL. Medication adherence and the associated health-economic impact among patients with type 2 diabetes mellitus converting to insulin pen therapy: an analysis of third-party managed care claims data. Clinical Therapeutics. 2006 Oct; 28(10): 1712-25. doi: 10.1016/j.clinthera.2006.10.004. DOI: https://doi.org/10.1016/j.clinthera.2006.10.004
Zeru MA, Tesfa E, Mitiku AA, Seyoum A, Bokoro TA. Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis. Scientific Reports. 2021 Nov; 11(1): 21733. doi: 10.1038/s41598-021-01256-9. DOI: https://doi.org/10.1038/s41598-021-01256-9
World Health Organization. Adherence to long-term therapies: evidence for action. World Health Organization; 2003.
Adisa R, Alutundu MB, Fakeye TO. Factors contributing to nonadherence to oral hypoglycemic medications among ambulatory type 2 diabetes patients in Southwestern Nigeria. Pharmacy Practice. 2009 Jul; 7(3): 163. doi: 10.4321/S1886-36552009000300006. DOI: https://doi.org/10.4321/S1886-36552009000300006
García-Pérez LE, Álvarez M, Dilla T, Gil-Guillén V, Orozco-Beltrán D. Adherence to therapies in patients with type 2 diabetes. Diabetes Therapy. 2013 Dec; 4: 175-94. doi: 10.1007/s13300-013-0034-y. DOI: https://doi.org/10.1007/s13300-013-0034-y
Kasznicki J, Głowacka A, Drzewoski J. Type 2 diabetic patients compliance with drug therapy and glycaemic control. Diabetologia Doświadczalna i Kliniczna. 2007 Jul; 7(4): 199-203.
Boshe BD, Yimar GN, Dadhi AE, Bededa WK. The magnitude of non-adherence and contributing factors among adult outpatient with Diabetes Mellitus in Dilla University Referral Hospital, Gedio, Ethiopia. PloS One. 2021 Mar; 16(3): e0247952. doi: 10.1371/journal.pone.0247952. DOI: https://doi.org/10.1371/journal.pone.0247952
Abate TW. Medication non-adherence and associated factors among diabetes patients in Felege Hiwot Referral Hospital, Bahir Dar city administration, Northwest Ethiopia. BMC Research Notes. 2019 Dec; 12(1): 1-6. doi: 10.1186/s13104-019-4205-4. DOI: https://doi.org/10.1186/s13104-019-4205-4
Demoz GT, Berha AB, Alebachew Woldu M, Yifter H, Shibeshi W, Engidawork E. Drug therapy problems, medication adherence and treatment satisfaction among diabetic patients on follow-up care at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. PloS One. 2019 Oct; 14(10): e0222985. doi: 10.1371/journal.pone.0222985. DOI: https://doi.org/10.1371/journal.pone.0222985
Kusa W, Tolessa D, Abdeta T. Type II DM medication non-adherence in Adama Hospital Medical College, Central Ethiopia. East African Journal of Health and Biomedical Sciences. 2019 May; 3(1): 31-8.
Kirkman MS, Rowan-Martin MT, Levin R, Fonseca VA, Schmittdiel JA, Herman WH, et al. Determinants of adherence to diabetes medications: findings from a large pharmacy claims database. Diabetes Care. 2015 Apr; 38(4): 604-9. doi: 10.2337/dc14-2098. DOI: https://doi.org/10.2337/dc14-2098
Mitiku Y, Belayneh A, Tegegne BA, Kebede B, Abebe D, Biyazin Y, et al. Prevalence of Medication Non-Adherence and Associated Factors among Diabetic Patients in A Tertiary Hospital at Debre Markos, Northwest Ethiopia. Ethiopian Journal of Health Sciences. 2022 Jul; 32(4): 755-764. doi: 10.4314/ejhs.v32i4.12. DOI: https://doi.org/10.4314/ejhs.v32i4.12
Foley L, Larkin J, Lombard-Vance R, Murphy AW, Hynes L, Galvin E, et al. Prevalence and predictors of medication non-adherence among people living with multimorbidity: a systematic review and meta-analysis. BMJ Open. 2021 Sep; 11(9): e044987. doi: 10.1136/bmjopen-2020-044987. DOI: https://doi.org/10.1136/bmjopen-2020-044987
Ali M, Alemu T, Sada O. Medication adherence and its associated factors among diabetic patients at Zewditu Memorial Hospital, Addis Ababa, Ethiopia. BMC Research Notes. 2017 Dec; 10(1): 1-5. doi: 10.1186/s13104-017-3025-7. DOI: https://doi.org/10.1186/s13104-017-3025-7
Bonger Z, Shiferaw S, Tariku EZ. Adherence to diabetic self-care practices and its associated factors among patients with type 2 diabetes in Addis Ababa, Ethiopia. Patient Prefer Adherence. 2018 Jun; 12: 963-970. doi: 10.2147/PPA.S156043. DOI: https://doi.org/10.2147/PPA.S156043
Nandini HC, Gali A, Muraraiah S. Assessment of factors influencing adherence to antidiabetic drugs among patients with type 2 diabetes mellitus at a tertiary care hospital in India. Pharmacology and Clinical Pharmacy Research. 2020 Apr; 5(1): 7-13. doi: 10.15416/pcpr.v5i1.26507. DOI: https://doi.org/10.15416/pcpr.v5i1.26507
Aminde LN, Tindong M, Ngwasiri CA, Aminde JA, Njim T, Fondong AA, et al. Adherence to antidiabetic medication and factors associated with non-adherence among patients with type-2 diabetes mellitus in two regional hospitals in Cameroon. BMC Endocrinology Disorders. 2019 Apr; 19(1): 35. doi: 10.1186/s12902-019-0360-9. DOI: https://doi.org/10.1186/s12902-019-0360-9
Araya EM, Gebrezgabiher HA, Tekulu GH, Alema NM, Getnet D, Gebru HT, et al. Medication non-adherence and associated factors among diabetic patients visiting general hospitals in the eastern zone of Tigrai, Northern Ethiopia. Patient Preference and Adherence. 2020 Oct; 14: 2071-83. doi: 10.2147/PPA.S278148. DOI: https://doi.org/10.2147/PPA.S278148
Bagonza J, Rutebemberwa E, Bazeyo W. Adherence to anti diabetic medication among patients with diabetes in eastern Uganda; a cross sectional study. BMC Health Services Research. 2015 Dec; 15(1): 1-7. doi: 10.1186/s12913-015-0820-5. DOI: https://doi.org/10.1186/s12913-015-0820-5
Shams N, Amjad S, Ahmed W, Saleem F. Drug non-adherence in type 2 diabetes mellitus; predictors and associations. Journal of Ayub Medical College Abbottabad. 2016 Jun; 28(2): 302-7.
Parimalakrishnan S, Dussa K, Sahay R. Assessment of diabetes knowledge using diabetes knowledge questionnaire among people with type 2 diabetes mellitus. Asian Journal of Pharmaceutical and Clinical Research. 2015 Mar; 8(2): 254–56.
Imtiaz S, Ullah H, Rasool MF, Hashmat F, Saleem M, Khan N. Assesment of Compliance of Diabetic Patients at Nishtar Hospital Multan, Pakistan. Gomal Journal of Medical Sciences. 2014 Jun; 12(2): 84-8.
Tiv M, Viel JF, Mauny F, Eschwege E, Weill A, Fournier C, et al. Medication adherence in type 2 diabetes: the ENTRED study 2007, a French population-based study. PloS One. 2012 Mar; 7(3): e32412. doi: 10.1371/journal.pone.0032412. DOI: https://doi.org/10.1371/journal.pone.0032412
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Pakistan Journal of Health Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments
