Pregnancy Outcomes in Patients with Valvular Heart Disease

Pregnancy Outcomes in Patients

Authors

  • Hidayat Ullah Cardiac Center, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan
  • Muhammad Shafique Arshad Cardiac Center, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan
  • Zabih Ullah Khyber Teaching Hospital, Peshawar, Pakistan
  • Abdul Rehman Holy Family Hospital, Rawalpindi, Pakistan
  • Muhammad Khalil Cardiac Center, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan
  • Nouman Khan Cardiac Center, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v4i10.1094

Keywords:

Valvular Heart Disease, Pregnancy Outcome, Maternal Complications

Abstract

Valvular heart disorders (VHD) may affect both mother and fetus during pregnancy. This research examined pregnancy outcomes in valvular heart disease patients. Methods: This was a descriptive comparative study conducted at Department of Cardiology, PIMS, Islamabad, from April 10th to August 31st, 2023. The study consisted 318 females, 166 of them were healthy (control group) and 152 of them had valvular heart disease (study group). SPSS version 25 was used to analyze the data. Objectives: To evaluate the pregnancy outcomes of females with valvular heart disease presenting to tertiary care hospital. Results: Group-I contained 152 females with valvular heart disease and group-II had 166 healthy females. Group-I mean age was 20.2±4.8 years, whereas group-II mean age was 22.3±2.8 years (p>0.05). Stillbirths were greater in group-I 10(6.57%) and 2(1.20%) (p 0.001) than group-II. Mitral stenosis was the most common valvular lesion at 53.97% (82 patients). 18.42% (28 patients) had mitral regurgitation. The study group had 0.65% maternal mortality compared to 0% in the control group. 11 (7.23%) patients developed cardiac arrythmias in study group compared to 2 (1.20%) patients in control group. Conclusions: There is a high risk of pregnancy in pregnant females who has valvular heart disease is a and have higher probability of having fetomaternal complications.

References

Rousham E, Clark M, Latham M, Oo SP, Read S, Griffiths P, et al., Resilience and vulnerabilities of urban food environments in the Asia‐Pacific region. Maternal & Child Nutrition. 2023 Apr: 13513. doi: 10.1111/mcn.13513. DOI: https://doi.org/10.1111/mcn.13513

Coffey S, Roberts-Thomson R, Brown A, Carapetis J, Chen M, Enriquez-Sarano M, et al., Global epidemiology of valvular heart disease. Nature Reviews Cardiology. 2021 Dec; 18(12): 853-64. doi: 10.1038/s41569-021-00570-z. DOI: https://doi.org/10.1038/s41569-021-00570-z

Iung B and Vahanian A. Epidemiology of valvular heart disease in the adult. Nature Reviews Cardiology. 2011 Mar; 8(3): 162-72. doi: 10.1038/nrcardio.2010.202. DOI: https://doi.org/10.1038/nrcardio.2010.202

Altaf A, Faiz S, Badalyan SS, Khan R, Yahya S. The Effect of Valvular Heart Disease on Maternal and Fetal Outcome of Pregnancy in Young Pregnant Females. Pakistan Journal of Medical & Health Sciences. 2022 Nov; 16(09): 386-90. doi: 10.53350/pjmhs22169386. DOI: https://doi.org/10.53350/pjmhs22169386

Klein LL and Galan HL. Cardiac disease in pregnancy. Obstetrics and Gynecology Clinics. 2014 Jun; 31(2): 429-59. doi: 10.1016/j.ogc.2004.03.001. DOI: https://doi.org/10.1016/j.ogc.2004.03.001

Stout KK and Otto CM. Pregnancy in women with valvular heart disease. Heart. 2017 May; 93(5): 552-8. doi: 10.1136/hrt.2005.067975. DOI: https://doi.org/10.1136/hrt.2005.067975

Canobbio MM, Warnes CA, Aboulhosn J, Connolly HM, Khanna A, Koos BJ, et al., Management of pregnancy in patients with complex congenital heart disease: a scientific statement for healthcare professionals from the American Heart Association. Circulation. 2017 Feb; 135(8): 50-87. doi: 10.1161/CIR.0000000000000458. DOI: https://doi.org/10.1161/CIR.0000000000000458

Jeejeebhoy FM, Zelop CM, Lipman S, Carvalho B, Joglar J, Mhyre JM, et al., Cardiac arrest in pregnancy: a scientific statement from the American Heart Association. Circulation. 2015 Nov; 132(18): 1747-73. doi: 10.1161/CIR.0000000000000300. DOI: https://doi.org/10.1161/CIR.0000000000000300

Lachtrupp CL, Valente AM, Gurvitz M, Landzberg MJ, Brainard SB, Wu FM, et al., Associations between clinical outcomes and a recently proposed adult congenital heart disease anatomic and physiological classification system. Journal of the American Heart Association. 2021 Sep; 10(18): 021345. doi: 10.1161/JAHA.120.021345. DOI: https://doi.org/10.1161/JAHA.120.021345

Perloff JS and Koos B. Management of Pregnancy and Contraception in Congenital. Congenital Heart Disease in Adults. 2018 Aug:194.

Hameed A, Karaalp IS, Tummala PP, Wani OR, Canetti M, Akhter MW, et al., The effect of valvular heart disease on maternal and fetal outcome of pregnancy. Journal of The American College of Cardiology. 2011 Mar; 37(3): 893-9. doi: 10.1016/S0735-1097(00)01198-0. DOI: https://doi.org/10.1016/S0735-1097(00)01198-0

Van Hagen IM, Thorne SA, Taha N, Youssef G, Elnagar A, Gabriel H, et al., Pregnancy outcomes in women with rheumatic mitral valve disease: results from the registry of pregnancy and cardiac disease. Circulation. 2018 Feb; 137(8): 806-16. doi: 10.1161/CIRCULATIONAHA.117.032561. DOI: https://doi.org/10.1161/CIRCULATIONAHA.117.032561

Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin III JP, Guyton RA, et al., 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014 Jun; 129(23): 521-643. doi: 10.1161/CIR.0000000000000031. DOI: https://doi.org/10.1161/CIR.0000000000000031

Elkayam U and Bitar F. Valvular heart disease and pregnancy: part I: native valves. Journal of The American College of Cardiology. 2005 Jul; 46(2): 223-30. doi: 10.1016/j.jacc.2005.02.085. DOI: https://doi.org/10.1016/j.jacc.2005.02.085

Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Barón-Esquivias G, Baumgartner H, et al., Guidelines on the management of valvular heart disease (version 2012) The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). European Heart Journal. 2019; 33(19): 2451-2496.

Stone GW, Adams DH, Abraham WT, Kappetein AP, Généreux P, Vranckx P, et al., Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: a consensus document from the Mitral Valve Academic Research Consortium. European Heart Journal. 2015 Aug; 36(29):1878-91. doi.org/10.1093/eurheartj/ehv333. DOI: https://doi.org/10.1093/eurheartj/ehv333

Salem DN, Stein PD, Al-Ahmad A, Bussey HI, Horstkotte D, Miller N, et al., Antithrombotic therapy in valvular heart disease—native and prosthetic: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2014 Sep; 126(3): 457-82. doi: 10.1378/chest.126.3_suppl.457S. DOI: https://doi.org/10.1378/chest.126.3_suppl.457S

Rychik J, Atz AM, Celermajer DS, Deal BJ, Gatzoulis MA, Gewillig MH, et al., Evaluation and management of the child and adult with Fontan circulation: a scientific statement from the American Heart Association. Circulation. 2019 Aug; 140(6): 234-84. doi: 10.1161/CIR.0000000000000696. DOI: https://doi.org/10.1161/CIR.0000000000000696

Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD. Practice guidelines for the management of patients with valvular heart disease: executive summary. Journal of The American College of Cardiology. 2016 Aug; 48(3): 598-675. doi: 10.1016/j.jacc.2006.05.030. DOI: https://doi.org/10.1016/j.jacc.2006.05.030

Meissner MH, Wakefield TW, Ascher E, Caprini JA, Comerota AJ, Eklof B, et al., Acute venous disease: venous thrombosis and venous trauma. Journal of Vascular Surgery. 2007 Dec; 46(6): 25-53. doi: 10.1016/j.jvs.2007.08.037. DOI: https://doi.org/10.1016/j.jvs.2007.08.037

Downloads

Published

2023-10-31
CITATION
DOI: 10.54393/pjhs.v4i10.1094
Published: 2023-10-31

How to Cite

Ullah, H., Arshad, M. S., Ullah, Z., Rehman, A., Khalil, M., & Khan, N. (2023). Pregnancy Outcomes in Patients with Valvular Heart Disease: Pregnancy Outcomes in Patients. Pakistan Journal of Health Sciences, 4(10), 170–174. https://doi.org/10.54393/pjhs.v4i10.1094

Issue

Section

Original Article

Plaudit