An Evaluation of Platelet Indices in Newly Diagnosed Cases of Acute Myocardial Infarction: Platelet Indices and Acute Myocardial Infarction

Muhammad Bilal Ghafoor; Faiza Sarwar; Babar Bashir; Farah Yasmeen; Sumrah Abbasi; Zeeshan Hameed

doi:10.54393/pjhs.v5i04.1449

Authors

Muhammad Bilal Ghafoor Department of Pathology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
Faiza Sarwar Department of Pathology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
Babar Bashir Department of Cardiology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
Farah Yasmeen Department of Pathology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
Sumrah Abbasi Department of Pathology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
Zeeshan Hameed Department of Pathology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i04.1449

Keywords:

Myocardial Infarction, Platelet Indices, Platelet Crit, Hematological Parameters

Abstract

Acute myocardial infarction (AMI) is characterized by prothrombotic phenotype associated with endothelial dysfunction, an increase in platelet activation and systemic inflammation. Platelet aggregation and activation are crucial in the formation of thrombi and acceleration of atherosclerosis, associated with unstable angina, sudden cardiac death is brought on by an acute myocardial infarction. Objective: To evaluate the platelet-indices in newly diagnosed cases of acute myocardial infarction. Methods: This cross-sectional study was conducted during November 2022 to December 2023 in Pathology Department of Sheikh Zayed Medical College/Hospital Rahim Yar Khan. Samples were collected from the patients of AMI admitted to Emergency Ward and from healthy controls as well. Complete Blood Count (CBC) with platelet indices, platelet count, Mean Platelet Volume (MPV), Platelet Crit (PCT) and Platelet Distribution Width (PDW) were investigated on five-part automated hematology analyzer BT-PRO 2300. Analysis of the data was done by using SPSS version 20.0. Results: Total 140 patients were divided into a healthy control group (70) and newly diagnosed cases of acute myocardial infarction (70). Among diagnosed cases of AMI 46 (65.7%) had ST-elevation myocardial infarction (STEMI) and 24 cases (34.2%) got non-ST-elevation myocardial infarction (NSTEMI). It was found that AMI patients had lower platelet counts and PCT with higher MPV and PDW. Conclusions: It was concluded that the platelet indices (PDW, and PCT, MPV) are significant predictors of myocardial infarction. They might be applied as an easy, reliable, and economical way to anticipate an impending acute coronary event.

References

Sharma D, Pandey M, Rishi JP. A Study of platelet volume indices in patients of coronary artery diseases. Journal of Scientific and Innovative Research. 2016; 5(5): 161-4. doi:

31254/jsir.2016.5501.

World Health Organization. HEARTS: Technical package for cardiovascular disease management in primary health care: Risk-based CVD management. 2020. [Last cited: 29th Apr 2024]. Available at: https://www.who.int/publications/i/item/9789240001367.

Shao C, Wang J, Tian J, Tang YD. Coronary artery disease: from mechanism to clinical practice. Coronary Artery Disease: Therapeutics and Drug Discovery. 2020: 1-36. doi: 10.1007/978-981-15-2517-9_1.

UpToDate. Acute coronary syndrome: Terminology and classification. 2024. [Last cited: 29th Apr 2024]. Available at: https://sso.uptodate.com/contents/acute-coronary-syndrome-terminology-and-classification.

Lyon A. Medicine for Final and Beyond. John S editors. Oxford University Press; 2022.

Nasir AA, Osaro E, Mohammed I, Marafa AH. Role of Platelets in the Pathogenicity of Atherosclerosis and Thrombosis in Coronary Heart Diseases. Sokoto Journal of Medical Laboratory Science. 2021 Nov; 6(3). doi: 10.4314/sokjmls.v6i3.13.

Scridon A. Platelets and their role in hemostasis and thrombosis—From physiology to pathophysiology and therapeutic implications. International Journal of Molecular Sciences. 2022 Oct; 23(21): 12772. doi: 10.3390/ijms232112772.

Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. Mean platelet volume (MPV): new perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators of Inflammation. 2019 Oct; 2019. doi: 10.1155/2019/9213074.

Yi P, Jiang J, Wang Z, Wang X, Zhao M, Wu H et al. Comparison of mean platelet volume (MPV) and red blood cell distribution width (RDW) between psoriasis patients and controls: A systematic review and meta-analysis. PLoS One. 2022 Feb; 17(2): e0264504. doi: 10.1371/journal.pone.0264504.

Tran VH, Mehawej J, Abboud DM, Tisminetzky M, Hariri E, Filippaios A et al. Age and sex differences and temporal trends in the use of invasive and noninvasive procedures in patients hospitalized with acute myocardial infarction. Journal of the American Heart Association. 2022 Sep; 11(17): e025605. doi: 10.1161/JAHA.122.025605.

Ashraf S, Rashid A, Mughal Z, Babar H, Sheikh H, Naveed MA. Spectrum of Aplastic Anaemia; presentation, etiology and overall survival: ASpectrum of Aplastic Anaemia: Presentation, Etiology and Overall Survival-A Tertiary Care Hospital Experience Tertiary Care Hospital Experience: Spectrum of Aplastic Anaemia. Pakistan BioMedical Journal. 2022 May; 330-4. doi: 10.54393/pbmj.v5i5.437.

Mohamed A-AB, Elnady HM, Alhewaig HK, Moslem Hefny H, Khodery A. The mean platelet volume and plateletcrit as predictors of short-term outcome of acute ischemic stroke. The Egyptian Journal of Neurology, psychiatry and neurosurgery. 2019; 55(1): 1-6. doi: 10.1186/s41983-018-0035-x.

Alvitigala BY, Azra MA, Kottahachchi DU, Jayasekera MM, Wijesinghe RA. A study of association between platelet volume indices and ST elevation myocardial infarction. IJC Heart & Vasculature. 2018 Dec; 21: 7-10. doi: 10.1016/j.ijcha.2018.09.001.

El Said AM, Naseem Hussien M, Mohmaed Allaithy A, Abd-Elfatah Saed AM. The Role of Hematological Indices in Patients with Acute Coronary Syndrome. Cardiology and Angiology: An International Journal. 2022 Jan; 11(1): 1-10. doi: 10.9734/ca/2022/v11i130184.

Dahlen B, Schulz A, Göbel S, Tröbs SO, Schwuchow‐Thonke S, Spronk HM et al. The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study. ESC Heart Failure. 2021 Aug; 8(4): 2991-3001. doi: 10.1002/ehf2.13390.

Hassan NA, El-Ddin TM, Kafafy TA, Mahran EH. Platelet indices and blood cell ratios in acute coronary syndrome and their predictive values. Journal of Current Medical Research and Practice. 2020 Jan; 5(1): 57-62. doi: 10.4103/JCMRP.JCMRP_51_19.

Budzianowski J, Pieszko K, Burchardt P, Rzeźniczak J, Hiczkiewicz J. The role of hematological indices in patients with acute coronary syndrome. Disease Markers. 2017 Oct; 2017. doi: 10.1155/2017/3041565.

Saxena S, Saxena N, Jain R, Jasani J. Analysis of Platelet Volume Indices in Patients with Acute Coronary Syndrome in Gujarat, India. Indian Journal of Forensic Medicine & Toxicology. 2021 Apr; 15(2). doi: 10.37506/ijfmt.v15i2.14914.

Assiri AS, Jamil AM, Mahfouz AA, Mahmoud ZS, Ghallab M. Diagnostic importance of platelet parameters in patients with acute coronary syndrome admitted to a tertiary care hospital in southwest region, Saudi Arabia. Journal of Saudi Heart Association. 2012 Jan; 24(1): 17-21. doi: 10.1016/j.jsha.2011.08.004.

Pipliwal PS, Singh G, Ishran R, Bansal S. Mean platelet volume and other platelet volume indices in patients with acute myocardial infarction: A case-control study. Journal of Dental and Medical Sciences. 2015; 14(11): 35-8.