Risk Factors and Prevalence of Hepatitis B and C in Badin City, Pakistan

Prevalence and Risk Factors of Hepatitis

Authors

  • Yasir Akbar Jamali Department of Physiology, University of Sindh, Jamshoro, Pakistan
  • Rukia Farzana Khairpur Medical College, Khairpur, Pakistan
  • Jawad Ahmad Khan Department of Pharmacy, Shah Abdul Latif University, Khairpur, Pakistan
  • Amjad Ali Mughal Institute of Microbiology, Shah Abdul Latif University, Khairpur, Pakistan
  • Hira Saeed Khan Department of Physiology, Suleman Roshan Medical College, Tando Adam, Pakistan
  • Sadia Kazi Department of Pharmacology, Isra University, Hyderabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i05.1599

Keywords:

Hepatitis B, Viral Infection, Blood Transfusion, Polymerase Chain Reaction

Abstract

Hepatitis is a global health concern, and its ever increasing prevalence in Pakistan has highlighted the need to study its epidemiology and develop preventative strategies. Objective: To determine the frequency and identify the risk factors associated with hepatitis virus infections B and C among the population of Badin city. Methods: Seven hundred sixty-seven people were tested for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) using immunochromatographic methods. Additional testing was performed on blood samples from individuals who tested positive for hepatitis, and quantitative Polymerase Chain Reaction (PCR) was used to determine the viral load. Results: A total of 767 individuals had hepatitis. Among these, the research found that HCV was more common than HBV. However, men were more affected than women. Data on the exposure to risk factors for hepatitis B and C among the patients in our study are presented in Table 2 Of the 767 respondents, 473 (61.7%) were shaved from a barber/beauty parlour. Approximately 358 (46.7%) patients with hepatitis reused syringes. Drug addiction was observed in 66 (8.6%) patients. A history of blood transfusion was observed in 73 patients (9.5 %). Obstetrical procedures, ear pricks, and nose piercings were reported in 195 (68.1%), 245 (85.7%) and 240 (83.9%) female patients with hepatitis, respectively. Conclusions: Barbers, blood transfusions, and intravenous drug use are the most common risk factors for the spread of HBV and HCV are barbers, blood transfusions, and Intravenous Drug Use (IDUs), although newer variables, including piercings of the nose and ears and IDPs, also contribute

References

Kulkarni AV and Duvvuru NR. Management of hepatitis B and C in special population. World Journal of Gastroenterology. 2021 Oct; 27(40): 6861. doi: 10.3748/wjg.v27.i40.6861. DOI: https://doi.org/10.3748/wjg.v27.i40.6861

Al-Busafi SA and Alwassief A. Global Perspectives on the Hepatitis B Vaccination: Challenges, Achievements, and the Road to Elimination by 2030. Vaccines. 2024 Mar; 12(3): 288. doi: 10.3390/vaccines12030288. DOI: https://doi.org/10.3390/vaccines12030288

Anwar F, Khan M, Salman M, Ahmad S, Ullah F, Khan J et al. Seroprevalence of hepatitis B virus in human population of district Buner Khyber Pakhtunkhwa Pakistan. Clinical Epidemiology and Global Health. 2021 Apr; 10: 100688. doi: 10.1016/j.cegh.2020.100688. DOI: https://doi.org/10.1016/j.cegh.2020.100688

Dekker SE, Green EW, Ahn J. Treatment and prevention of acute hepatitis B virus. Clinics In Liver Disease. 2021 Nov; 25(4): 711-24. doi: 10.1016/j.cld.2021.06.002. DOI: https://doi.org/10.1016/j.cld.2021.06.002

Zahoor S, Khan A, Asif S, Tabraiz SA, Mustafa H, Ansar S et al. Past and future perspectives for hepatitis B and C in Pakistan. Cureus. 2021 Aug; 13(8): e17521. doi: 10.7759/cureus.17521. DOI: https://doi.org/10.7759/cureus.17521

Seerat I, Mushtaq H, Rafiq M, Nadir A. Frequency and associated risk factors of hepatitis B virus and hepatitis C virus infections in children at a hepatitis prevention and treatment clinic in Lahore, Pakistan. Cureus. 2020 May; 12(5). doi: 10.7759/cureus.7926. DOI: https://doi.org/10.7759/cureus.7926

Shafiq M, Nadeem M, Sattar Z, Khan SM, Faheem SM, Ahsan I et al. Identification of risk factors for hepatitis B and C in Peshawar, Pakistan. HIV/AIDS-Research and Palliative Care. 2015 Aug: 223-31. doi: 10.2147/HIV.S67429. DOI: https://doi.org/10.2147/HIV.S67429

Abbas Z and Abbas M. The cost of eliminating hepatitis C in Pakistan. The Lancet Global Health. 2020 Mar; 8(3): e323-4. doi: 10.1016/S2214-109X(20)30036-X. DOI: https://doi.org/10.1016/S2214-109X(20)30036-X

Al Kanaani Z, Mahmud S, Kouyoumjian SP, Abu-Raddad LJ. The epidemiology of hepatitis C virus in Pakistan: systematic review and meta-analyses. Royal Society Open Science. 2018 Apr; 5(4): 180257. doi: 10.1098/rsos.180257. DOI: https://doi.org/10.1098/rsos.180257

Mansoor M, De Glanville WA, Alam R, Aslam K, Ahmed M, Isaakidis P et al. Prevalence and risk factors for hepatitis C virus infection in an informal settlement in Karachi, Pakistan. PLOS Global Public Health. 2023 Sep; 3(9): e0002076. doi: 10.1371/journal.pgph.0002076. DOI: https://doi.org/10.1371/journal.pgph.0002076

Qureshi H, Bile KM, Jooma R, Alam SE, Afrid HU. Prevalence of hepatitis B and C viral infections in Pakistan: findings of a national survey appealing for effective prevention and control measures. EMHJ-Eastern Mediterranean Health Journal. 2010; 16: 15-23. doi: 10.26719/2010.16. DOI: https://doi.org/10.26719/2010.16.Supp.15

Trickey A, May MT, Davies C, Qureshi H, Hamid S, Mahmood H et al. Importance and contribution of community, social, and healthcare risk factors for hepatitis C infection in Pakistan. The American Journal of Tropical Medicine and Hygiene. 2017 Dec; 97(6): 1920. doi: 10.4269/ajtmh.17-0019. DOI: https://doi.org/10.4269/ajtmh.17-0019

Ghazal P. Rising trend of substance abuse in Pakistan: a study of sociodemographic profiles of patients admitted to rehabilitation centres. Public Health. 2019 Feb; 167: 34-7. doi: 10.1016/j.puhe.2018.10.020. DOI: https://doi.org/10.1016/j.puhe.2018.10.020

Shayan SJ, Nazari R, Kiwanuka F. Prevalence of HIV and HCV among injecting drug users in three selected WHO-EMRO countries: a meta-analysis. Harm Reduction Journal. 2021 May; 18(1): 59. doi: 10.1186/s12954-021-00505-4. DOI: https://doi.org/10.1186/s12954-021-00505-4

Mokhtari M, Basirkazeruni H, Rostami M. The correlation between different risk factors of hepatitis C and different genotypes. Advanced Biomedical Research. 2017 Jan; 6(1): 45. doi: 10.4103/2277-9175.204588. DOI: https://doi.org/10.4103/2277-9175.204588

Khan A, Afzal S, Yaqoob A, Fatima R, Ul Haq M, Junaid K et al. Epidemiology of viral hepatitis B and C in Punjab, Pakistan: a multicenter cross-sectional study, 2017-18. F1000Research. 2019 Dec; 8: 2065. doi: 10.12688/f1000research.20174.1.

Huang WC, Lin YC, Chen PJ, Hsu NT, Tu CL, Chang TS et al. Community-based screening for hepatitis B and C infectivity using two quantitative antigens to identify endemic townships. Viruses. 2022 Feb; 14(2): 304. doi: 10.3390/v14020304. DOI: https://doi.org/10.3390/v14020304

Ali F, Tahir M, Ali W, Habib M, Zeeshan M, Ullah H. Hepatitis B and C: Prevalence and Evaluation of its Associated Risk Factors in General Population of Okara District. The Journal of Microbiology and Molecular Genetics. 2023 Dec; 4(3): 95-105. doi: 10.52700/jmmg.v4i3.125. DOI: https://doi.org/10.52700/jmmg.v4i3.125

Naqvi IH, Talib A, Baloch G, Mahmood K, Qadari Z. Hepatitis B and C: frequency, modes of transmission and risk factors along with some unorthodox routes of spread. Pakistan Journal of Public Health. 2019 Sep; 9(3): 161-5. doi: 10.32413/pjph.v9i3.273. DOI: https://doi.org/10.32413/pjph.v9i3.273

Noreen A, Adnan F, Alam N, Syed Z, Aftab A, Shamim F et al. Prevalence and Associated Risk Factors Analysis of Hepatitis B & C Infections in the Low Socioeconomic Communities; A Cross-Sectional Study from Pakistan. 2022 Mar; 17(5): 291-303. doi: 10.2217/fvl-2021-0060. DOI: https://doi.org/10.2217/fvl-2021-0060

Asad M, Ahmed F, Zafar H, Farman S. Frequency and determinants of Hepatitis B and C virus in general population of Farash Town, Islamabad. Pakistan Journal of Medical Sciences. 2015 Nov; 31(6): 1394. doi: 10.12669/pjms.316.7047. DOI: https://doi.org/10.12669/pjms.316.7047

Khan M, Hussain U, Irshad A, Khan A. Prevalence of hepatitis B and C seropositivity in patients presenting for dental treatment. Pakistan Oral and Dental Journal. 2015 Jun; 35(2): 250-253.

Maan MA, Fatma H, Muhammad J. Epidemiology of hepatitis C viral infection in Faisalabad, Pakistan: a retrospective study (2010-2012). African Health Sciences. 2014 Dec; 14(4): 810-4. doi: 10.4314/ahs.v14i4.6. DOI: https://doi.org/10.4314/ahs.v14i4.6

Janjua NZ and Nizamy MA. Knowledge and practices of barbers about hepatitis B and C transmission in Rawalpindi and Islamabad. Journal of Pakistan Medical Association. 2004 Mar; 54(3): 116-9.

Hussain S and Ali Z. Prevalence of hepatitis B virus in the Kurram Agency, Pakistan: A 5-year observational study in a war-affected region. Journal of Clinical Virology. 2016 Sep; 82: 17-9. doi: 10.1016/j.jcv.2016.06.009. DOI: https://doi.org/10.1016/j.jcv.2016.06.009

Irshad H, Aziza F, Rahman AU. Frequency and associated risk factors of hepatitis B and C infection in Tehsil fort Abbas, Pakistan. Pakistan Journal of Medical Research. 2021 May; 60(1): 44-8.

Bibi S, Dars S, Ashfaq S, Qazi RA, Akhund S. Seroprevalence and risk factors for hepatitis C virus (HCV) infection in pregnant women attending public sector tertiary care hospital in Hyderabad Sindh. Pakistan Journal of Medical Sciences. 2013 Apr; 29(2): 505. doi: 10.12669/pjms.292.3211. DOI: https://doi.org/10.12669/pjms.292.3211

Akhtar N, Ilyas M, Muhammad K, Shams S, Saeed K, Asadullah A. Prevalence of Hepatitis C virus infections among the general population of Buner, Khyber Pakhtunkhwa, Pakistan. Biomedical Research and Therapy. 2016 Dec; 3(12): 1003-17. doi: 10.15419/bmrat.v3i12.139. DOI: https://doi.org/10.15419/bmrat.v3i12.139

Rana NA, Munir B, Hussain N, Imtiaz N. Seroprevalence, biochemical investigation and risk factor assessment for HBV & HCV Infection in Hospital Based Patients of Islamabad, Pakistan. Journal of Bioresource Management. 2020; 7(2): 2. doi: 10.35691/JBM.0202.0127. DOI: https://doi.org/10.35691/JBM.0202.0127

Saleem HA, Roman U, Mughal HH. Prevalence of Hepatitis B and C and associated risk factors in rural areas of Punjab. Pakistan Journal of Medical and Health Sciences. 2020 Oct; 14(4): 2062-3.

Memon AR, Shafique K, Memon A, Draz AU, Rauf MU, Afsar S. Hepatitis B and C prevalence among the high risk groups of Pakistani population. A cross sectional study. Archives of Public Health. 2012 Dec; 70: 1-6. doi: 10.1186/0778-7367-70-9. DOI: https://doi.org/10.1186/0778-7367-70-9

Alibrahim OA, Misau YA, Mohammed A, Faruk MB, Izzeldin SS. Prevalence of hepatitis C viral infection among injecting drug users in a Saudi Arabian hospital: a point cross sectional survey. Journal of Public Health in Africa. 2018 May; 9(1): 726. doi: 10.4081/jphia.2018.726. DOI: https://doi.org/10.4081/jphia.2018.726

Fayyaz M, Ghous SM, Ullah F, Abbas I, Ahmed N, Ahmed A. Frequency of hepatitis B and C in patients seeking treatment at the dental section of a tertiary care hospital. Journal of Ayub Medical College Abbottabad. 2015 Jun; 27(2): 395-7.

Akhtar AM, Majeed S, Jamil M, Rehman A. Prevalence of hepatitis C infection: General patients attending various hospitals of Lahore, Pakistan: a cross sectional study. The Professional Medical Journal. 2015 Nov; 22(11): 1390-6. doi: 10.29309/TPMJ/2015.22.11.861. DOI: https://doi.org/10.29309/TPMJ/2015.22.11.861

Ataei B, Alavian SM, Shahriari-Fard F, Rabiei AA, Safaei A, Rabiei A et al. A case-control study of risk factors for hepatitis B infection: A regional report among Isfahanian adults. Journal of Research in Medical Sciences. 2019 Jan; 24(1): 22. doi: 10.4103/jrms.JRMS_761_18. DOI: https://doi.org/10.4103/jrms.JRMS_761_18

IJAZ RR and Bhatti S. Risk of hepatitis C in factory workers and their relatives. Biomedica. 2013; 29(1): 42-3.

Mansour-Ghanaei R, Joukar F, Souti F, Atrkar-Roushan Z. Knowledge and attitude of medical science students toward hepatitis B and C infections. International Journal of Clinical and Experimental Medicine. 2013; 6(3): 197-205.

Ali A, Khan S, Malik SM, Iqbal MH, Aadil M. Comparison of knowledge and attitudes regarding hepatitis B among healthcare professionals in Pakistan. Cureus. 2017 Feb; 9(2): e1049. doi: 10.7759/cureus.1049. DOI: https://doi.org/10.7759/cureus.1049

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Published

2024-05-31
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DOI: 10.54393/pjhs.v5i05.1599
Published: 2024-05-31

How to Cite

Akbar Jamali, Y., Farzana, R., Khan, J. A., Mughal, A. A., Khan, H. S., & Kazi, S. (2024). Risk Factors and Prevalence of Hepatitis B and C in Badin City, Pakistan: Prevalence and Risk Factors of Hepatitis . Pakistan Journal of Health Sciences, 5(05), 126–131. https://doi.org/10.54393/pjhs.v5i05.1599

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