Changes in Liver Function and Lipid Profile during Underactive Thyroid Phase in Patients after Subtotal Thyroidectomy: Changes in Liver Function and Lipid Profile during Underactive Thyroid Phase

Zainab Haq; Syed Usama  Shayan Zaidi; Muhammad Umar; Muhammad Shazib Ali; Ali Bin Waseem; Areeba Imran; Muhammad Nauman Shahid

doi:10.54393/pjhs.v5i07.1664

Authors

Zainab Haq Quaid-e-Azam Medical College, Bahawalpur, Pakistan
Syed Usama Shayan Zaidi Department of Physiology, Shahida Islam Medical College, Lodhran, Pakistan
Muhammad Umar Department of Anatomy, Nawaz Sharif Medical College, Gujrat, Pakistan
Muhammad Shazib Ali Department of Biochemistry, Rashid Latif Khan University, Lahore, Pakistan
Ali Bin Waseem Lahore Medical and Dental College, Lahore, Pakistan
Areeba Imran Lahore Medical and Dental College, Lahore, Pakistan
Muhammad Nauman Shahid Lahore Medical and Dental College, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i07.1664

Keywords:

Sub-Total Thyroidectomy, Hypothyroidism, Thyroid-Stimulating Hormone, Alanine Transaminase, Alkaline Phosphatase, Aspartate Aminotransferase

Abstract

Underactive Thyroid Phase or Hypothyroidism is a very common biochemical complication after sub-total thyroidectomy. Objectives: To investigate lipid profile and liver function in patients who developed hypothyroidism following sub-total thyroidectomy. Methods: Total 100 individuals were selected for present study and divided them into two different groups i.e. Group-A in which 37 healthy individuals were placed whereas in Group-B 63 individuals were adopted surgical process, sub-total thyroidectomy. The study was conducted in Surgical and Medical Units of Ghurki Trust & Teaching Hospital, Lahore from December 2023 to April 2024. Thyroid-stimulating hormone (TSH) levels were extremely high in individuals in the hypothyroid stage. Results: The comparative findings of this study showed a significant (p < 0.05) change in cholesterol, triglyceride, LDL and HDL blood serum levels of Group-B individuals as compared to the Group-B. While a significant (p < 0.05) amplification in enzymes of liver such as aspartate aminotransferase (AST), alanine transaminase (ALT), and decrease in alkaline phosphatase (ALP) in Group-B subjects were seen as compared to normal individuals. Conclusions: Sub-total thyroidectomy is associated with hypothyroidism, which correlates with disruptions in liver enzyme activity and lipid metabolism, potentially leading to secondary hyperlipidemia and liver dysfunction.

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