Relationship Between Serum Osteocalcin Levels and Glycosylated Hemoglobin in Type II Diabetes Patients: Osteocalcin Levels and Glycosylated Hemoglobin in Diabetes Patients

Maria  Mufti; Nida  Khaliq; Mehtab  Munir; Almas  Khattak; Arsalan  Mufti; Fakeha  Ansari; Bilqis  Hassan; Farrukh  Ansar

doi:10.54393/pjhs.v3i06.369

Authors

Maria Mufti Department of Physiology, Federal Medical and Dental College, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan
Nida Khaliq Fazaia Medical College, Air University, Islamabad, Pakistan
Mehtab Munir Department of Physiology, Federal Medical and Dental College, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan
Almas Khattak Department of Medicine, Northwest School of Medicine, Peshawar, Pakistan
Arsalan Mufti Department of Emergency Medicine, Ziauddin University Hospital, Karachi, Pakistan
Fakeha Ansari Foundation University College of Dentistry, Rawalpindi, Pakistan
Bilqis Hassan Department of Medical Education, Northwest School of Medicine, Peshawar, Pakistan
Farrukh Ansar Quaid e Azam International Hospital, Islamabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v3i06.369

Keywords:

Osteocalcin levels, HbA1c levels, Type 2 Diabetes Mellitus

Abstract

Diabetic osteopathy is a complication of diabetes that elevates the risk of bone fractures and influences bone remodeling. Osteocalcin is a bone protein produced by osteoblasts that plays a role in the regulation of glucose and energy metabolism. Objectives: To explore the relationship between the level of glycosylated hemoglobin (HbA1c) and osteocalcin in diabetic patients. Methods: This cross-sectional analytical study was carried out at Hayatabad Medical Complex, Peshawar from January 2017 to February 2018. A total of 100 patients suffering from Type 2 Diabetes Mellitus (T2DM) were recruited. HbA1c and osteocalcin levels were measured by the enzymatic method and electrochemiluminescence immunoassay, respectively. SPSS was utilized for data entry and analysis; Pearson’s correlation was performed to assess the relationship between variables while statistical significance was accepted at p < 0.05. Results: The mean (SD) age of participants was 50 (9.2), while 58% of the study population was female. The mean (SD) HbA1c and osteocalcin levels were 11.3 (8.8) and 13.1 (6.8), respectively. The results of the correlation analysis yielded a negative relationship between HbA1c and osteocalcin levels (r =-0.099), but the results were statistically non-significant (p-value =0.328). Conclusion: Our study suggested that osteocalcin level has a negative correlation with HbA1c level in Type 2 Diabetes Mellitus patients

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