Roles of Different Radiations in Treatment of Breast Cancer: Radiations in Treatment of Breast Cancer

Usba  Jameel; Zubair  Janan Orakzai; Shamoona  Rashid; Sumaira  Noureen

doi:10.54393/pjhs.v3i07.416

Authors

Usba Jameel Khyber Teaching Hospital Peshawar, Pakistan
Zubair Janan Orakzai Department of Radiology, Medical Teaching Institution, Mardan Medical Complex, Mardan, Pakistan
Shamoona Rashid Department of Radiology, Aziz Fatima Medical and Dental College, Faisalabad, Pakistan
Sumaira Noureen Medical Teaching Institution, Mardan Medical Complex, Mardan, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v3i07.416

Keywords:

Radiation Therapy, Breast Cancer Radiotherapy, Radiation Therapy

Abstract

The review aimed to describe the role of radiations in treatment of breast cancer. The review also describe that which type of radiation is used to treat different stages of breast cancer i.e, metastatic stage, advance stage and early stage of breast cancer. The radiation therapy plays a significant role in the treatment of breast cancer. The treatment delivery methods are considerably changed in the recent decades. The concept of using radiotherapy for the treatment of breast cancer has remained equally important for oncologists throughout the years still research has been going on to make these radiotherapy sessions more and more convenient for the patients. The combination of breast conservation surgery an APBI can result in survival without having any other health related issues for other nearby organs. Recent findings have reported about incorporation of APBI into clinical usage. APBI should be used for patients with low risk of ductal carcinoma or in case of first stage of invasive ductal cancer which has prominent margins for the excision, and where the estrogen receptor positivity is clear. Radiation therapy is effectively used for the treatment and management of loco regionally advanced and distant metastatic disease. There is research going on to find most appropriate technique in which convenient and protected procedure is used for patients to avoid any side effects. New and advanced techniques are used to limit radiation related toxicity.

References

Van Leeuwen FE, Klokman WJ, Stovall M, Dahler EC, van’t Veer MB, Noordijk EM, et al. Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin’s disease. Journal of the National Cancer Institute. 2003 Jul; 95(13): 971-80. doi: 10.1093/jnci/95.13.971

Li F, Zheng X, Liu Y, Li P, Liu X, Ye F, et al. Different roles of CHOP and JNK in mediating radiation-induced autophagy and apoptosis in breast cancer cells. Radiation Research. 2016 May; 185(5): 539-48. doi: 10.1667/RR14344.1

Demaria S, Kawashima N, Yang AM, Devitt ML, Babb JS, Allison JP, et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clinical Cancer Research. 2005 Jan; 11(2): 728-34. doi: 10.1158/1078-0432.728.11.2

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, et al. Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research. 2013 Oct; 15(5): 1-37. doi: 10.1186/bcr3493

Majeed W, Aslam B, Javed I, Khaliq T, Muhammad F, Ali A, et al. Breast cancer: major risk factors and recent developments in treatment. Asian Pacific Journal of Cancer Prevention. 2014; 15(8): 3353-8. doi: 10.7314/APJCP.2014.15.8.3353

Hillner BE, Ingle JN, Berenson JR, Janjan NA, Albain KS, Lipton A, et al. American Society of Clinical Oncology guideline on the role of bisphosphonates in breast cancer. Journal of Clinical Oncology. 2000 Mar; 18(6): 1378-91. doi: 10.1200/JCO.2000.18.6.1378

Chinnaiyan AM, Prasad U, Shankar S, Hamstra DA, Shanaiah M, et al. Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proceedings of the National Academy of Sciences. 2000 Feb; 97(4): 1754-9. doi: 10.1073/pnas.030545097

Feng M, Moran JM, Koelling T, Chughtai A, Chan JL, Freedman L, et al. Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer. International Journal of Radiation Oncology* Biology* Physics. 2011 Jan; 79(1): 10-8. doi: 10.1016/j.ijrobp.2009.10.058

Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens‐Alvarado RL, et al. American cancer society/American society of clinical oncology breast cancer survivorship care guideline. CA: a cancer journal for clinicians. 2016 Jan; 66(1): 43-73. doi: 10.3322/caac.21319

Cui L, Song Z, Liang B, Jia L, Ma S, Liu X. Radiation induces autophagic cell death via the p53/DRAM signaling pathway in breast cancer cells. Oncology reports. 2016 Jun; 35(6): 3639-47. doi: 10.3892/or.2016.4752

Nadine A, Easton DF, Chang-Claude J, Rookus MA, Brohet RM, Cardis E, et al. Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort study: a report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators' Group. Journal of Clinical Oncology. 2006 Jul; 24(21): 3361-6. doi: 10.1200/JCO.2005.03.3126

Van Poznak CH, Temin S, Yee GC, Janjan NA, Barlow WE, Biermann JS, et al. American Society of Clinical Oncology Clinical Practice Guideline update on the role of bone-modifying agents in metastatic breast cancer. JCO Oncology Practice. 2011 Mar; 7(2): 117-21.

Weichselbaum RR, Ishwaran H, Yoon T, Nuyten DS, Baker SW, Khodarev N, et al. An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer. Proceedings of the National Academy of Sciences. 2008 Nov; 105(47): 18490-5. doi: 10.1073/pnas.0809242105

Nandi S, Guzman RC, Yang J. Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis. Proceedings of the National Academy of Sciences. 1995 Apr; 92(9): 3650-7. doi: 10.1073/pnas.92.9.3650

Akram M, Iqbal M, Daniyal M, Khan AU. Awareness and current knowledge of breast cancer. Biological research. 2017 Dec; 50(1): 1-23. doi: 10.1186/s40659-017-0140-9

Yu L, Yang Y, Hou J, Zhai C, Song Y, Zhang Z, et al. MicroRNA-144 affects radiotherapy sensitivity by promoting proliferation, migration and invasion of breast cancer cells. Oncology reports. 2015 Oct; 34(4): 1845-52. doi: 10.3892/or.2015.4173

Fan S, Smith ML, Rivert DJ, Duba D, Zhan Q, Kohn KW, et al. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer research. 1995 Apr 15; 55(8): 1649-54.

Feng Y, Spezia M, Huang S, Yuan C, Zeng Z, Zhang L, et al. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes & diseases. 2018 Jun; 5(2): 77-106. doi: 10.1016/j.gendis.2018.05.001

Hussain A, Bourguet-Kondracki ML, Hussain F, Rauf A, Ibrahim M, Khalid M, et al. The potential role of dietary plant ingredients against mammary cancer: a comprehensive review. Critical Reviews in Food Science and Nutrition. 2022 Mar; 62(10): 2580-605. doi: 10.1080/10408398.2020.1855413

Gulati G, Heck SL, Ree AH, Hoffmann P, Schulz-Menger J, Fagerland MW, et al. Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2× 2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol. European heart journal. 2016 Jun; 37(21): 1671-80. doi: 10.1093/eurheartj/ehw022

Horwitz KB, Koseki Y, Mcguire WI. Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen. Endocrinology. 1978 Nov; 103(5): 1742-51. doi: 10.1210/endo-103-5-1742

Schagen SB, van Dam FS, Muller MJ, Boogerd W, Lindeboom J, Bruning PF. Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma. Cancer: Interdisciplinary International Journal of the American Cancer Society. 1999 Feb; 85(3): 640-50. doi: 10.1002/(SICI)1097-0142(19990201)85: 3%3C640: : AID-CNCR14%3E3.0.CO; 2-G

Bartelink H, Maingon P, Poortmans P, Weltens C, Fourquet A, Jager J, et al. Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial. The lancet oncology. 2015 Jan; 16(1): 47-56. doi: 10.1016/S1470-2045(14)71156-8

Farnie G, and Clarke RB. Mammary stem cells and breast cancer—role of Notch signalling. Stem cell reviews. 2007 Jun; 3(2): 169-75. doi: 10.1007/s12015-007-0023-5

Ghayad SE, and Cohen PA. Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients. Recent patents on anti-cancer drug discovery. 2010 Jan; 5(1): 29-57. doi: 10.2174/157489210789702208