Frequency of Macrosomia in Neonates Among Women with Gestational Diabetes Mellitus
Macrosomia in Neonates Among Women
DOI:
https://doi.org/10.54393/pjhs.v4i04.674Keywords:
Gestational Diabetes Mellitus, MacrosomiaAbstract
One of the most frequent pregnancy complications is gestational diabetes mellitus (GDM), which raises the risk of unfavorable health issues for both mother and fetus. Macrosomia and increased fetal growth are significant contributors to poor perinatal outcomes. Objective: To determine the frequency of macrosomia in neonates among women with gestational diabetes mellitus. Methods: This Descriptive study was done in Department of Obstetrics and Gynecology, Dow University Health Sciences Karachi from 3rd April 2018 to 2nd october 2018.We enrolled 100 patients meeting the criteria. Informed consent was taken. Results: The average age of the patients was 31.16 ± 4.37years, mean gestational age 38.51 ± 2.7 weeks while Mean BMI of the patients was 28.74 ± 1. 3. Frequency of macrosomia in neonates among women with gestational diabetes mellitus was observed in 14%. Conclusions: It is concluded that there was a significant number of macrosomia associated with women having gestational diabetes. So, it needs prompt diagnosis and expert management to decrease maternal and fetal morbidity and mortality.
References
Tobias DK, Zhang C, Van Dam RM, Bowers K, Hu FB. Physical activity before and during pregnancy and risk of gestational diabetes mellitus a meta-analysis. Diabetes Care. 2011 Jan; 34(1): 223-9. doi: 10.2337/dc10-1368.
Eslamian L, Akbari S, Marsoosi V, Jamal A. Effect of different maternal metabolic characteristics on fetal growth in women with gestational diabetes mellitus. Iran Journal of Reproductive Medicine. 2013 Apr; 11(4): 325.2.
Ghiasi A, Ziaei S, Faghihzadeh S. The relationship between levels of lipids and lipoprotein B-100 in maternal serum and umbilical cord serum and assessing their effects on newborn infants anthropometric indices. Journal of Midwifery and Reproductive Health. 2014 Oct; 2(4): 227-32.
Kulkarni SR, Kumaran K, Rao SR, Chougule SD, Deokar TM, Bhalerao AJ et al. Maternal lipids are as important as glucose for fetal growth. Diabetes Care. 2013 Sep; 36(9): 2706-13. doi: 10.2337/dc12-2445.
Stuebe AM, Mantzoros C, Kleinman K. Gestational glucose tolerance and maternal metabolic profile at 3 years postpartum. Obstetrics and Gynaecology. 2011 Nov; 118(5): 1065-73. doi: 10.1097/AOG.0b013e3182325f5a.
Martino J, Sebert S, Segura MT, Garcia-Valdes L, Florido J, Padilla MC, et al. Maternal body weight and gestational diabetes differentially influence placental and pregnancy outcomes. Journal of Clinical Endocrinology and Metabolism. 2015 Oct; 101(1): 59-68. doi: 10.1210/jc.2015-2590.
Lewis RM, Demmelmair H, Gaillard R, Godfrey KM, Hauguel-deMouzon S, Huppertz B, et al. The placental exposome: placental determinants of fetal adiposity and postnatal body composition. Annals of Nutrition and Metabolism. 2013 Oct; 63(3): 208-15. doi: 10.1159/000355222.
Jawad F and Irshaduddin PK. Prevalence of gestational diabetes and pregnancy outcome in Pakistan. Eastern Mediterranean Health Journal. 1996; 2(2): 268-73. doi: 10.26719/1996.2.2.268.
Bener A, Saleh NM, Al-Hamaq A. Prevalence of gestational diabetes and associated maternal and neonatal complications in a fast-developing community: global comparisons. International Journal of women's Health. 2011 Nov: 367-73. doi: 10.2147/IJWH.S26094.
Chauhan SP, Grobman WA, Gherman RA, Chauhan VB, Chang G, Magann EF, et al. Suspicion and treatment of the macrosomic fetus: a review. American journal of obstetrics and gynecology. 2005 Aug; 193(2): 332-46. doi: 10.1016/j.ajog.2004.12.020.
Alam M, Raza SJ, Sherali AR, Akhtar AS. Neonatal complications in infants born to diabetic mothers. Journal of the College of Physicians and Surgeons--pakistan: JCPSP. 2006 Mar; 16(3): 212-5.
Eslamian L, Akbari S, Marsoosi V, Jamal A. Association between fetal overgrowth and metabolic parameters in cord blood of newborns of women with GDM. Minervamedica. 2013 Jun; 104(3): 317-24.
Shaikh F, Zeeshan F, Hakeem R, Basit A, Fawwad A, Hussain A. Maternal dietary intake and anthropometric measurements of newborn at birth. The Open Diabetes Journal. 2014 Jun; 7(1): 14-9. doi: 10.2174/1876524601407010014
Schaefer-Graf UM, Graf K, Kulbacka I, Kjos SL, Dudenhausen J, Vetter K, et al. Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus. Diabetes Care. 2008 Sep; 31(9): 1858-63. doi: 10.2337/dc08-0039.
Baptiste-Roberts K, Barone BB, Gary TL, Golden SH, Wilson LM, Bass EB, Nicholson WK. Risk factors for type 2 diabetes among women with gestational diabetes: a systematic review. The American Journal of Medicine. 2009 Mar; 122(3): 207-14. doi: 10.1016/j.amjmed.2008.09.034.
Okun N, Verma A, Mitchell BF, Flowerdew G. Relative importance of maternal constitutional factors and glucose intolerance of pregnancy in the development of newborn macrosomia. The Journal of Maternal‐Fetal Medicine. 1997 Sep; 6(5): 285-90. doi: 10.1002/(SICI)1520-6661(199709/10)6:5<285::AID-MFM9>3.0.CO;2-C.
Stotland NE, Caughey AB, Breed EM, Escobar GJ. Risk factors and obstetric complications associated with macrosomia. International Journal of Gynecology & Obstetrics. 2004 Dec; 87(3): 220-6. doi: 10.1016/j.ijgo.2004.08.010.
Gibson JR, McKeown T. Observations on all births (23, 970) in Birmingham, 1947. VII. Effect of changing family size on infant mortality. British Journal of Social Medicine. 1952 Jul; 6(3): 183-7. doi: 10.1136/jech.6.3.183.
Boinpally T and Jovanovič L. Management of type 2 diabetes and gestational diabetes in pregnancy. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine: A Journal of Translational and Personalized Medicine. 2009 Jun; 76(3): 269-80. doi: 10.1002/msj.20115.
O'Reilly MW, Avalos G, Dennedy MC, O'Sullivan EP, Dunne F. Atlantic DIP: high prevalence of abnormal glucose tolerance post-partum is reduced by breast-feeding in women with prior gestational diabetes mellitus. European Journal of Endocrinology. 2011 Dec; 165(6): 953-9. doi: 10.1530/EJE-11-0663.
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