Effect of Vitamin D Supplement on Axial Length of Myopes
Effect of Vitamin D Supplement
DOI:
https://doi.org/10.54393/pjhs.v4i05.778Keywords:
Vitamin D, Myopia, EmmetropesAbstract
Myopia is triggered on by excessive axial elongation. Vitamin D deficiency somehow relevant to myopia genic visual cues. Objectives: To compare the level of vitamin D 25(OH)D in myopes and emmetropes and to access the effect of vitamin D 25(OH)D supplements in different degrees of myopia and compare the axial length. Methods: A Randomize Controlled Trail Study was conducted in Madina Teaching Hospital, Faisalabad on 60 subjects from September 2022 to April 2023 with age ranges 15-25 years. All were subjected to following examinations; BCVA, slit-lamp examination, A-scan and vitamin D level. The sample was randomly divided into two groups through Non-probability Purposive Sampling Technique. Group 1 was emmetropic, whereas group 2 exhibits various degrees of myopia. Group 2 takes up supplemental vitamin D followed by 1 month. Results: Mean age was 20.82 years ± 2.32. Out of the total 60 subjects, 24 (40%) were male while 36 (60%) were female.47 subjects (78.3%) reported having less than 4 hours of outdoor exposure while 13 subjects (21%) reported having more than 4 hours. Mean axial length 21.97 ± .80 and 22.66 ± 1.29 of emmetropes (p=0.008) while myopes 24.30 ± .91 and 24.13 ± 1.04 at baseline and after one month respectively (p=0.023). Mean vitamin D level was 18.36 ± 1.37and 17.13 ± 1.35 of emmetropes (p=0.00) while 15.63 ± 1.54and 16.90 ± 2.75 at baseline and after one month respectively (p=0.00). Conclusions: There was a significant association between low levels of vitamin D and the development of myopia in emmetropes and vitamin D supplementation can help to prevent the axial length elongation of myopes
References
Bullimore MA, Lee SS, Schmid KL, Rozema JJ, Leveziel N, Mallen EA, et al. IMI—onset and progression of myopia in young adults. Investigative Ophthalmology & Visual Science. 2023 May; 64(6): 2-.doi: 10.1167/iovs.64.6.2.
CW Klaver C, Polling JR, Erasmus Myopia Research Group. Myopia management in the Netherlands. Ophthalmic and Physiological Optics. 2020 Mar; 40(2): 230-40. doi: 10.1111/opo.12676.
Bourke CM, Loughman J, Flitcroft DI, Loskutova E, O’Brien C. We can’t afford to turn a blind eye to myopia. QJM: An International Journal of Medicine. 2019 Mar: 1-13. doi: 10.1093/qjmed/hcz076.
Buckhurst H, Gilmartin B, Cubbidge R, Logan NS. Conformation of the anterior segment in human myopia. Ophthalmic and Physiological Optics. 2023 May; 43(3): 368-76. doi: 10.1111/opo.13095.
Liu G, Rong H, Zhang P, Xue Y, Du B, Wang B, et al. The effect of axial length elongation on corneal biomechanical property. Frontiers in Bioengineering and Biotechnology. 2021 Dec; 9: 777239. doi: 10.3389/fbioe.2021.777239.
Swenor BK. Including disability in all health equity efforts: an urgent call to action. The Lancet Public Health. 2021 Jun; 6(6): 359-60. doi: 10.1016/S2468-2667(21)00115-8.
Demir P, Baskaran K, Theagarayan B, Gierow P, Sankaridurg P, Macedo AF. Refractive error, axial length, environmental and hereditary factors associated with myopia in Swedish children. Clinical and Experimental Optometry. 2021 Jul; 104(5): 595-601. doi: 10.1080/08164622.2021.1878833.
Atowa UC, Wajuihian SO, Munsamy AJ. Associations between near work, outdoor activity, parental myopia and myopia among school children in Aba, Nigeria. International Journal of Ophthalmology. 2020 Feb; 13(2): 309-16. doi: 10.18240/ijo.2020.02.16.
Jiang L, Huang G, Dai C, Zheng R, Xie C, Duan S, et al. Association of genetic variants in PDGFRA with high myopia in the Han population of southwestern China. Ophthalmic Genetics. 2022 Mar; 43(2): 184-90. doi: 10.1080/13816810.2021.1998550.
Rashid F, Jabbar M, Fatima N, Siddique M, Hussain A, Waheed K. Effect of Change in Iris Color on Myopia. Pakistan Journal of Medical & Health Sciences. 2022 May; 16(04): 289-. doi: 10.53350/pjmhs22164289.
Zhang JS, Da Wang J, Zhu GY, Li J, Xiong Y, Yusufu M, et al. The expression of cytokines in aqueous humor of high myopic patients with cataracts. Molecular Vision. 2020 Mar; 26:150-57.
Hanyuda A, Torii H, Hayashi K, Uchida A, Mori K, Yotsukura E, et al. Relationship of choroidal thickness and axial length with posterior vitreous detachment in patients with high myopia. Scientific Reports. 2022 Mar; 12(1): 4093. doi: 10.1038/s41598-022-08101-7.
Jabbar M, Fatima N, Siddique M, Rashid F, Qureshi F, Bodla AM. Association between Myopia and Glaucoma; A Cross-sectional Study: Association between Myopia and Glaucoma. Pakistan Journal of Health Sciences. 2023 Apr; 4(4): 133-7. doi: 10.54393/pjhs.v4i04.667.
Ha A, Kim CY, Shim SR, Chang IB, Kim YK. Degree of myopia and glaucoma risk: a dose-response meta-analysis. American Journal of Ophthalmology. 2022 Apr; 236: 107-19. doi: 10.1016/j.ajo.2021.10.007.
Lingham G, Mackey DA, Zhu K, Lucas RM, Black LJ, Oddy WH, et al. Time spent outdoors through childhood and adolescence–assessed by 25‐hydroxyvitamin D concentration–and risk of myopia at 20 years. Acta Ophthalmologica. 2021 Sep; 99(6): 679-87. doi: 10.1111/aos.14709.
Zhang RH, Yang Q, Dong L, Li YF, Zhou WD, Wu HT, et al. Association between vitamin D and myopia in adolescents and young adults: Evidence of national cross-sectional study. European Journal of Ophthalmology. 2023 Mar:11206721231161498. doi: 10.1177/11206721231161498.
Hinduja AR, Chandy D, Patkar D, Wankhedkar H. Vitamin-D deficiency in adults of Mumbai city: Change in the last decade. Journal of Family Medicine and Primary Care. 2022 May; 11(5): 2187. doi: 10.4103/jfmpc.jfmpc_1804_21.
Sediqi MS, Mansoor AR, Mangal M. Prevalence of hypovitaminosis D among children and adolescents of Kabul: a descriptive cross-sectional study. BMC Pediatrics. 2023 Dec; 23(1): 1-6. doi: 10.1186/s12887-023-03861-1.
Aaraj S, Kausar A, Khan SA. Vitamin D deficiency: A risk factor for myopia in children—a cross sectional study in a tertiary care centre. JPMA. The Journal of the Pakistan Medical Association. 2022 Jun; 72(6): 1075-9. doi: 10.47391/JPMA.2323.
Bikle D and Christakos S. New aspects of vitamin D metabolism and action—Addressing the skin as source and target. Nature Reviews Endocrinology. 2020 Apr; 16(4): 234-52. doi: 10.1038/s41574-019-0312-5.
Polzonetti V, Pucciarelli S, Vincenzetti S, Polidori P. Dietary intake of vitamin D from dairy products reduces the risk of osteoporosis. Nutrients. 2020 Jun; 12(6): 1743. doi: 10.3390/nu12061743.
Kessi‐Pérez EI, González A, Palacios JL, Martínez C. Yeast as a biological platform for vitamin D production: A promising alternative to help reduce vitamin D deficiency in humans. Yeast. 2022 Sep; 39(9): 482-92. doi: 10.1002/yea.3708.
Jastrzębska J, Skalska M, Radzimiński Ł, López-Sánchez GF, Weiss K, Hill L, et al. Changes of 25 (OH) D concentration, bone resorption markers and physical performance as an effect of sun exposure, supplementation of vitamin D and lockdown among young soccer players during a one-year training season. Nutrients. 2022 Jan; 14(3): 521. doi: 10.3390/nu14030521.
O’Brien KM, Sandler DP, Xu Z, Kinyamu HK, Taylor JA, Weinberg CR. Vitamin D, DNA methylation, and breast cancer. Breast Cancer Research. 2018 Dec; 20(1): 1-1. doi: 10.1186/s13058-018-0994-y.
Anderson CM, Gillespie SL, Thiele DK, Ralph JL, Ohm JE. Effects of maternal vitamin D supplementation on the maternal and infant epigenome. Breastfeeding Medicine. 2018 Jun; 13(5): 371-80. doi: 10.1089/bfm.2017.0231.
Pignolo A, Mastrilli S, Davì C, Arnao V, Aridon P, dos Santos Mendes FA, et al. Vitamin D and Parkinson’s disease. Nutrients. 2022 Mar; 14(6): 1220. doi: 10.3390/nu14061220.
Veleva N, Dimtrova G, Oscar A, Kemilev P, Mladenov O, Dimitrov G, et al. Vitamin D status in children with myopia. Bulgarian Review of Ophthalmology. 2020 Jun; 64(1): 33-7. doi: /10.14748/bro.v64i1.6668.
Choi JA, Han K, Park YM, La TY. Low serum 25-hydroxyvitamin D is associated with myopia in Korean adolescents. Investigative Ophthalmology & Visual Science. 2014 Apr; 55(4): 2041-7. doi: 10.1167/iovs.13-12853.
Yazar S, Hewitt AW, Black LJ, McKnight CM, Mountain JA, Sherwin JC, et al. Myopia is associated with lower vitamin D status in young adults. Investigative Ophthalmology & Visual Science. 2014 Jul; 55(7): 4552-59. doi: 10.1167/iovs.14-14589.
Tideman JW, Polling JR, Voortman T, Jaddoe VW, Uitterlinden AG, Hofman A, et al. Low serum vitamin D is associated with axial length and risk of myopia in young children. European Journal of Epidemiology. 2016 May; 31(5): 491-9. doi: 10.1007/s10654-016-0128-8.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Pakistan Journal of Health Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments