Analysis of Serum Electrolytes Variation in Onset and Progression of Preeclampsia
Serum Electrolytes Variation in Preeclampsia
DOI:
https://doi.org/10.54393/pjhs.v4i09.1047Keywords:
Preeclampsia, Electrolyte Imbalance, Trace Minerals, Electrolytes, Pregnancy ComplicationsAbstract
Preeclampsia is one of the most common, life-threatening complications of pregnancy that is related to maternal as well as perinatal morbidity or mortality. One of the significant causes of preeclampsia is elevated blood pressure which is directly linked with concentrations of electrolytes in the blood. Objective: To evaluate the possible variations of electrolytes in preeclamptic pregnant females. Methods: A total of 90 pregnant females of 20 to 45 years of age were divided into three groups (n=30 in each group) viz normotensive, hypertensive, and preeclamptic pregnant females. All anthropometric and biophysical variables were measured. Among biochemical parameters, serum sodium, potassium, chloride, and calcium levels were determined using colorimetric assays while bicarbonate levels were determined by an enzymatic test using phosphoenolpyruvate carboxylase and a stable nicotinamide dihydrogen phosphate analogue. A comparison of serum electrolytes among different groups was executed by one-way analysis of variance. Results: Preeclamptic females had significantly higher BMI, and systolic and diastolic blood pressure than hypertensive and normotensive pregnant females (p<0.0001). Serum concentrations of sodium and calcium were significantly lower in preeclamptic pregnant females compared to hypertensive pregnant and normotensive pregnant females (p<0.0001). Conclusions: Alteration in the electrolyte levels may contribute to the onset and progression of preeclampsia. Nutritional sodium restriction along with adjuvant supplementation of Ca⁺⁺, Na⁺, K⁺, and Clˉ may minimize the risk of preeclampsia. On the basis of outcomes, it is recommended that pregnant females should eat a balanced diet that contains appropriate amounts of minerals micronutrients, and vitamins.
References
Tariq M, Rehmani H, Tayyab M, Kamal F, Yasmeen N, Sultan F. Clinico-pathological study of pre-eclampsia. Biomedica. 2000 Jul; 16: 60-5.
Soomro S, Kumar R, Lakhan H, Shaukat F. Risk factors for pre-eclampsia and eclampsia disorders in tertiary care center in Sukkur, Pakistan. Cureus. 2019 Nov; 11(11): e61145. doi: 10.7759/cureus.6115. DOI: https://doi.org/10.7759/cureus.6115
Meads C, Cnossen J, Meher S, Juarez-Garcia A, Ter Riet G, Duley L, et al. Methods of prediction and prevention of pre-eclampsia: systematic reviews of accuracy and effectiveness literature with economic modelling. Health Technology Assessment. 2008 Mar; 12: 6. doi: 10.3310/hta12060. DOI: https://doi.org/10.3310/hta12060
Osmond C, Kajantie E, Forsén TJ, Eriksson JG, Barker DJ. Infant growth and stroke in adult life: the Helsinki birth cohort study. Stroke. 2007 Feb; 38(2): 264-70. doi: 10.1161/01.STR.0000254471.72186.03. DOI: https://doi.org/10.1161/01.STR.0000254471.72186.03
Fox R, Kitt J, Leeson P, Aye CY, Lewandowski AJ. Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring. Journal of Clinical Medicine. 2019 Oct; 8(10): 1625. doi: 10.3390/jcm8101625. DOI: https://doi.org/10.3390/jcm8101625
Harvard T. Chan School of Public Health. Three of the B vitamins: folate, vitamin B. 2021. [Last cited: 27th Sep 2023]. Available at: https://www.hsph.harvard.edu/nutritionsource/vitamins/vitamin-b/.
Powel JE, Rosenthal E, Roman A, Chasen ST, Berghella V. Preeclampsia and low sodium (PALS): a case and systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2020 Jun; 249: 14-20. doi: 10.1016/j.ejogrb.2020.03.052. DOI: https://doi.org/10.1016/j.ejogrb.2020.03.052
Naylor DF and Olson MM. Critical care obstetrics and gynecology. Critical Care Clinics. 2003 Jan; 19(1): 127-49. doi: 10.1016/S0749-0704(02)00059-3. DOI: https://doi.org/10.1016/S0749-0704(02)00059-3
Ulrich S, von Tempelhoff GF, Heilmann L. The Na+/K+ cotransporter of the erythrocyte membrane in pregnancy-induced hypertension. Zentralblatt fur Gynakologie. 1994 Jan; 116(3): 164-8.
Arumanayagam M and Rogers M. Platelet sodium pump and sodium potassium cotransport activity in nonpregnant, normotensive, and hypertensive pregnant women. Hypertension in Pregnancy. 1999 Jan; 18(1): 35-44. doi: 10.3109/10641959909009609. DOI: https://doi.org/10.3109/10641959909009609
Young SL, Hage ML, Li J. Another case of excessive caffeine and hypokalemia in pregnancy. Obstetrics & Gynecology. 2001 Nov; 98(5 Part 1): 874. doi: 10.1097/00006250-200111000-00030. DOI: https://doi.org/10.1097/00006250-200111000-00030
Mohammed MI and Inuwa Y. Determination of serum chloride ion concentration in pregnant women from Minjibir local government area, Kano State Nigeria. Chemsearch Journal. 2012 Jun; 3(1): 19-23.
Sidahmed MAE and Abubaker N. Serum total calcium, magnesium, sodium and potassium in sudanese with preeclampsia. International Journal of Advanced Research. 2017 Feb; 5: 2061-6. doi: 10.21474/IJAR01/3378. DOI: https://doi.org/10.21474/IJAR01/3378
Sunitha T, Sameera K, Umaramani G. Study of Biochemical changes in Preeclamptic women. International Journal of Biological & Medical Research. 2012; 3(3): 2025-8.
Indumati V, Kodliwadmath M, Sheela M. The role of serum electrolytes in pregnancy induced hypertension. Journal of Clinical Diagnostic and Research. 2011 Feb; 5(1): 66-9.
Munazza B, Raza N, Naureen A, Khan SA, Fatima F, Ayub M, et al. Liver function tests in preeclampsia. Journal of Ayub Medical College Abbottabad. 2011 Dec; 23(4): 3-5.
Poorolajal J and Jenabi E. The association between body mass index and preeclampsia: a meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine. 2016 Nov; 29(22): 3670-6. doi: 10.3109/14767058.2016.1140738. DOI: https://doi.org/10.3109/14767058.2016.1140738
Adewolu O. Serum sodium, potassium, calcium and magnesium in women with pregnancy induced hypertension and preeclampsia in Oredo local Government, Benin Metropolis: A pilot study. African Journal of Medical and Health Sciences. 2013 Jan; 12(1): 1. doi: 10.4103/2384-5589.129914. DOI: https://doi.org/10.4103/2384-5589.129914
Owusu Darkwa E, Djagbletey R, Antwi-Boasiako C, Aryee G, Sottie D, Akowuah A. Serum sodium and potassium levels in preeclampsia: A case-control study in a large tertiary hospital in Ghana. Cogent Medicine. 2017 Jan; 4(1): 1376898. doi: 10.1080/2331205X.2017.1376898. DOI: https://doi.org/10.1080/2331205X.2017.1376898
Tabassum H, Al-Jameil N, Ali MN, Khan FA, Al-Rashed M. Status of serum electrolytes in preeclamptic pregnant women of Riyadh, Saudi Arabia. Biomedical Research. 2015 Apr; 26(2): 219-4.
Manjareeka MA and Nanda SI. Serum electrolyte levels in preeclamptic women: a comparative study. International Journal of Pharma and Bio Sciences. 2012 Jun; 3(2): 572-8.
Razavi AS, Chasen ST, Gyawali R, Kalish RB. Hyponatremia associated with preeclampsia. Journal of Perinatal Medicine. 2017 May; 45(4): 467-70. doi: 10.1515/jpm-2016-0062. DOI: https://doi.org/10.1515/jpm-2016-0062
Lumbers ER, Delforce SJ, Arthurs AL, Pringle KG. Causes and consequences of the dysregulated maternal renin-angiotensin system in preeclampsia. Frontiers in Endocrinology. 2019 Sep; 10: 563. doi: 10.3389/fendo.2019.00563. DOI: https://doi.org/10.3389/fendo.2019.00563
Beers K and Patel N. Kidney physiology in pregnancy. Advances in Chronic Kidney Disease. 2020 Nov; 27(6): 449-54. doi: 10.1053/j.ackd.2020.07.006. DOI: https://doi.org/10.1053/j.ackd.2020.07.006
Ahsan T, Banu S, Nahar Q, Ahsan M, Khan MN, Islam SN. Serum trace elements levels in preeclampsia and eclampsia: correlation with the pregnancy disorder. Biological Trace Element Research. 2013 Jun; 152: 327-32. doi: 10.1007/s12011-013-9637-4. DOI: https://doi.org/10.1007/s12011-013-9637-4
Kim J, Kim YJ, Lee R, Moon JH, Jo I. Serum levels of zinc, calcium, and iron are associated with the risk of preeclampsia in pregnant women. Nutrition Research. 2012 Oct; 32(10): 764-9. doi: 10.1016/j.nutres.2012.09.007. DOI: https://doi.org/10.1016/j.nutres.2012.09.007
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