A Narrative Review on Management of Cyanosis in Neonates
Management of Cyanosis in Neonates
DOI:
https://doi.org/10.54393/pjhs.v4i11.1106Keywords:
Cyanosis, Etiology, Evaluation, ManagementAbstract
A bluish coloring of the skin or mucous membrane that is characteristic of the medical condition cyanosis can be visible around the lips, fingers, and toes. It is one of the indications of respiratory distress in infants that can be brought on by inadequate circulation and low levels of oxygenated blood. There are two basic causes of cyanosis, cardiac and pulmonary. Medical professionals are constantly very concerned about accurately diagnosing and treating newborns with congenital heart disease (CHD), despite the fact that prenatal diagnostic methods have significantly improved. Although they are physiologically entirely different from one another, ductus dependent congenital cardiac abnormalities can be divided into the ductus dependent systemic or pulmonary sickness. When developing the treatment plan, the clinical state and cardiac abnormalities must be taken into consideration. Many life-threatening conditions may not show signs right away after delivery, and the majority of clinical and physical symptoms are ambiguous, which makes a diagnosis difficult. Careful evaluation is required, and when clinical data, electrocardiograms, and chest X-rays are used. The newborn must be identified as being at such high risk right once, and prompt medical attention is essential to reducing mortality and morbidity
References
Lees MH. Cyanosis of the newborn infant: recognition and clinical evaluation. The Journal of Pediatrics. 1970 Sep; 77(3): 484-98. doi: 10.1016/S0022-3476(70)80024-5. DOI: https://doi.org/10.1016/S0022-3476(70)80024-5
Azmi NF, Delbressine F, Feijs L. Conceptual determination and assessment of cyanosis. Int. J. Bioscience, Biochemistry and Bioinformatics. 2016 Jul; 6(3): 75-83. doi: 10.17706/ijbbb.2016.6.3.75-83. DOI: https://doi.org/10.17706/ijbbb.2016.6.3.75-83
Adeyinka A and Kondamudi NP. Cyanosis. StatPearls Publishing; 2018.
Eichenwald E and Kim M. Overview of cyanosis in the newborn. UpToDate. 2021 Apr; 2.
Pahal P and Goyal A. Central and peripheral cyanosis. StatPearls publishing; 2021.
Sasidharan P. An approach to diagnosis and management of cyanosis and tachypnea in term infants. Pediatric Clinics. 2004 Aug; 51(4): 999-1021. doi: 10.1016/j.pcl.2004.03.010. DOI: https://doi.org/10.1016/j.pcl.2004.03.010
Lundsgaard C. Studies on Cyanosis: I. Primary Causes of Cyanosis. The Journal of Experimental Medicine. 1919 Sep; 30(3): 259-69. doi: 10.1084/jem.30.3.259. DOI: https://doi.org/10.1084/jem.30.3.259
Lees MH and King DH. Cyanosis in the newborn. Pediatrics in Review. 1987 Aug; 9(2): 36-42. doi: 10.1542/pir.9-2-36. DOI: https://doi.org/10.1542/pir.9-2-36
Hiremath G and Kamat D. Diagnostic considerations in infants and children with cyanosis. Pediatric Annals. 2015 Feb; 44(2): 76-80. doi: 10.3928/00904481-20150203-12. DOI: https://doi.org/10.3928/00904481-20150203-12
Mutlu B, Keskin EY, Oliveira AC, Relvas L, Bento C. A Rare Cause of Cyanosis since Birth: Hb M-Iwate. Turkish Journal of Hematology. 2019 Dec; 36(4): 299. doi: 10.4274/tjh.galenos.2019.2019.0123. DOI: https://doi.org/10.4274/tjh.galenos.2019.2019.0123
Wilson R, Ross O, Griksaitis MJ. Tetralogy of fallot. BJA Education. 2019 Nov; 19(11): 362. doi: 10.1016/j.bjae.2019.07.003. DOI: https://doi.org/10.1016/j.bjae.2019.07.003
Benson JM and Therrell Jr BL. History and current status of newborn screening for hemoglobinopathies. Seminars in Perinatology. 2010 Apr; 34(2): 134-44. doi: 10.1053/j.semperi.2009.12.006. DOI: https://doi.org/10.1053/j.semperi.2009.12.006
Horn EP, Bein B, Steinfath M, Ramaker K, Buchloh B, Höcker J. The incidence and prevention of hypothermia in newborn bonding after cesarean delivery: a randomized controlled trial. Anesthesia & Analgesia. 2014 May; 118(5): 997-1002. doi: 10.1213/ANE.0000000000000160. DOI: https://doi.org/10.1213/ANE.0000000000000160
Jyotsna M, Srinivas B, Lalita N. Cyanosis–Part 1. Indian Journal of Cardiovascular Disease in Women-WINCARS. 2016 Dec; 1(04): 069-74. doi: 10.1055/s-0038-1656488. DOI: https://doi.org/10.1055/s-0038-1656488
Sattar SBA, Sharma S, Headley A. Bacterial Pneumonia (Nursing). StatPearls Publishing; 2021.
Stark AR and Eichenwald EC. Persistent pulmonary hypertension of the newborn. UpToDate. 2018; 10.
Teng RJ and Wu TJ. Persistent pulmonary hypertension of the newborn. Journal of the Formosan Medical Association. 2013 Apr; 112(4): 177-84. doi: 10.1016/j.jfma.2012.11.007. DOI: https://doi.org/10.1016/j.jfma.2012.11.007
Taleb M, Ashraf Z, Valavoor S, Tinkel J. Evaluation and management of acquired methemoglobinemia associated with topical benzocaine use. American Journal of Cardiovascular Drugs. 2013 Oct; 13: 325-30. doi: 10.1007/s40256-013-0027-2. DOI: https://doi.org/10.1007/s40256-013-0027-2
McMullen SM and Patrick W. Cyanosis. The American Journal of Medicine. 2013 Mar; 126(3): 210-2. doi: 10.1016/j.amjmed.2012.11.004. DOI: https://doi.org/10.1016/j.amjmed.2012.11.004
Das S and Maiti A. Acrocyanosis: an overview. Indian Journal of Dermatology. 2013 Nov; 58(6): 417. doi: 10.4103/0019-5154.119946. DOI: https://doi.org/10.4103/0019-5154.119946
Steinhorn RH. Evaluation and management of the cyanotic neonate. Clinical Pediatric Emergency Medicine. 2008 Sep; 9(3): 169-75. doi: 10.1016/j.cpem.2008.06.006. DOI: https://doi.org/10.1016/j.cpem.2008.06.006
Geggel RL. Diagnosis and initial management of cyanotic heart disease in the newborn. UpToDate. 2021.
Murty VY and Ram KD. Phrenic nerve palsy: a rare cause of respiratory distress in newborn. Journal of Pediatric Neurosciences. 2012 Sep; 7(3): 225. doi: 10.4103/1817-1745.106487. DOI: https://doi.org/10.4103/1817-1745.106487
Geggel R and Armsby C. Cardiac causes of cyanosis in the newborn. UpToDate. 2021 Apr; 11.
Movahedian AH, Mosayebi Z, Sagheb S. Evaluation of pulse oximetry in the early detection of cyanotic congenital heart disease in newborns. The Journal of Tehran University Heart Center. 2016 Apr; 11(2): 73.
Kitterman JA. Cyanosis in the newborn infant. Pediatrics in Review. 1982 Jul; 4(1): 13-23. doi: 10.1542/pir.4-1-13. DOI: https://doi.org/10.1542/pir.4-1-13
Gupta SK. Clinical approach to a neonate with cyanosis. The Indian Journal of Pediatrics. 2015 Nov; 82: 1050-60. doi: 10.1007/s12098-015-1871-7. DOI: https://doi.org/10.1007/s12098-015-1871-7
Cloherty JP, Eichenwald EC, Stark AR. Manual of neonatal care. Lippincott Williams & Wilkins; 2008.
Schieppati A, Henter JI, Daina E, Aperia A. Why rare diseases are an important medical and social issue. The Lancet. 2008 Jun; 371(9629): 2039-41. doi: 10.1016/S0140-6736(08)60872-7. DOI: https://doi.org/10.1016/S0140-6736(08)60872-7
Choi BS, Kwon BS, Kim GB, Bae EJ, Noh CI, Choi JY, et al. Long-term outcomes after an arterial switch operation for simple complete transposition of the great arteries. Korean Circulation Journal. 2010 Jan; 40(1): 23-30. doi: 10.4070/kcj.2010.40.1.23. DOI: https://doi.org/10.4070/kcj.2010.40.1.23
Rao PS. Diagnosis and management of cyanotic congenital heart disease: part I. The Indian Journal of Pediatrics. 2009 Jan; 76: 57-70. doi: 10.1007/s12098-009-0030-4. DOI: https://doi.org/10.1007/s12098-009-0030-4
Krishnan US. Approach to congenital heart disease in the neonate. The Indian Journal of Pediatrics. 2002 Jun; 69: 501-5. doi: 10.1007/BF02722652. DOI: https://doi.org/10.1007/BF02722652
Lin AE, Di Sessa TG, Williams RG, Leighton J, Gross K, Wong AL. Balloon and blade atrial septostomy facilitated by two-dimensional echocardiography. The American Journal of Cardiology. 1986 Feb; 57(4): 273-7. doi: 10.1016/0002-9149(86)90904-5. DOI: https://doi.org/10.1016/0002-9149(86)90904-5
Barron DJ, Kilby MD, Davies B, Wright JG, Jones TJ, Brawn WJ. Hypoplastic left heart syndrome. The Lancet. 2009 Aug; 374(9689): 551-64. doi: 10.1016/S0140-6736(09)60563-8. DOI: https://doi.org/10.1016/S0140-6736(09)60563-8
Tweddell JS, Hoffman GM, Fedderly RT, Berger S, Thomas Jr JP, Ghanayem NS, et al. Phenoxybenzamine improves systemic oxygen delivery after the Norwood procedure. The Annals of Thoracic Surgery. 1999 Jan; 67(1): 161-7. doi: 10.1016/S0003-4975(98)01266-1. DOI: https://doi.org/10.1016/S0003-4975(98)01266-1
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