Comparative Sero-Analysis between Copper Levels and the Risk of Acute Myocardial Infarction in District Nowshera

Copper Levels in Acute Myocardial Infarction Patients

Authors

  • Shabir Ahmed Orakzai Department of Pathology, Swat Medical College, Swat, Pakistan
  • Munaza Khattak Department of Physiology, Warsak Road Peshawar, Peshawar, Pakistan
  • Pervez Muhammad Department of Pathology, Jinnah Medical College, Peshawar, Pakistan
  • Aurangzeb Khan Department of Pathology, Swat Medical College, Swat, Pakistan
  • Farhan Abbas Baloch Department of Pathology, College of Medicine, Qassim University Kingdom of Saudi Arabia, Buraydah, Saudi Arabia
  • Haroon ur Rasheed Department of Pathology, Saidu Medical College Swat, Saidu, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i05.1463

Keywords:

Myocardial Infarction, Serum Copper Levels, Diabetes Mellitus, Dyslipidemia

Abstract

There is an increasing evidence pointing to a possible correlation between AMI and copper levels. Serum copper levels serve as a valuable biomarker for assessing the body's copper status. Objective: To find the changes in serum copper level in patients with Acute Myocardial Infarction (AMI). Methods: This observational study was conducted in District Headquarter Hospital, Nowshera in duration of two years. A total of 240 patients were recruited in this study. Upon admission, demographic information, medical history, and clinical characteristics were collected. Blood samples were obtained for measurement of serum copper levels using established laboratory methods. All data were analyzed through SPSS version 29.0. Results: Among total, 65% males and 35% females and the prevalence of cardiovascular risk factors was notable, with 70% of patients having hypertension, 40% with diabetes mellitus, 60% with dyslipidemia, and 45% identified as smokers. Baseline serum copper levels averaged 110 ± 5.2 µg/dL, within 24 hours of admission, the peak serum copper level significantly increased to 125 ± 18.6 µg/dL. Subsequently, levels decreased gradually over the following days, with mean values of 120 ± 17.1 µg/dL on Day 2, 115 ± 16.4 µg/dL on Day 3, 112 ± 15.9 µg/dL on Day 4, and returning to baseline levels by Day 5, 110 ± 15.2 µg/dL. Conclusions: Serum copper levels exhibit significant changes during the acute phase of AMI, with a peak observed within 24 hours of admission. While patients with anterior infractions showed higher peak copper levels, no significant associations were found between copper levels and traditional cardiovascular risk factors or inflammatory markers

References

Pagliaro BR, Cannata F, Stefanini GG, Bolognese L. Myocardial ischemia and coronary disease in heart failure. Heart Failure Reviews. 2020 Jan; 25(1): 53-65. doi: 10.1007/s10741-019-09831-z. DOI: https://doi.org/10.1007/s10741-019-09831-z

Katari V, Kanajam LS, Kokkiligadda S, Sharon T, Kantamaneni P. A review on causes of myocardial infarction and its management. World Journal of Pharmaceutical Research. 2023 Mar; 12(6): 511-29. doi: 10.20959/wjpr20236-27881.

Singh MM, Singh R, Khare A, Gupta MC, Patney NL, Jain VK et al. Serum copper in myocardial infarction-diagnostic and prognostic significance. Angiology. 1985 Aug; 36(8): 504-10. doi: 10.1177/000331978503600805. DOI: https://doi.org/10.1177/000331978503600805

Bagheri B, Akbari N, Tabiban S, Habibi V, Mokhberi V. Serum level of copper in patients with coronary artery disease. Nigerian Medical Journal. 2015 Jan; 56(1): 39-42. doi: 10.4103/0300-1652.149169. DOI: https://doi.org/10.4103/0300-1652.149169

Li X, Ling J, Hu Q, Fang C, Mei K, Wu Y et al. Association of serum copper (Cu) with cardiovascular mortality and all-cause mortality in a general population: a prospective cohort study. BMC Public Health. 2023 Nov; 23(1): 2138. doi: 10.1186/s12889-023-17018-3. DOI: https://doi.org/10.1186/s12889-023-17018-3

Mirończuk A, Kapica-Topczewska K, Socha K, Soroczyńska J, Jamiołkowski J, Kułakowska A et al. Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the serum of patients with acute ischemic stroke in Northeastern Poland-a new insight into stroke pathophysiology. Nutrients. 2021 Jun; 13(7): 2139. doi: 10.3390/nu13072139. DOI: https://doi.org/10.3390/nu13072139

Mandal R, Kaur S, Gupta VK, Joshi A. Heavy metals controlling cardiovascular diseases risk factors in myocardial infarction patients in critically environmentally heavy metal-polluted steel industrial town Mandi-Gobindgarh (India). Environmental Geochemistry and Health. 2022 Oct; 44(10): 3215-38. doi: 10.1007/s10653-021-01068-w. DOI: https://doi.org/10.1007/s10653-021-01068-w

Uddin SN, Rahaman MZ, Thammi TJ, Islam MR, Masud MI, Uddin MG et al. Low serum concentration of zinc, selenium, calcium, potassium and high serum concentration of iron, sodium are associated with myocardial infarction. Aging and Health Research. 2022 Mar; 2(1): 100063. doi: 10.1016/j.ahr.2022.100063. DOI: https://doi.org/10.1016/j.ahr.2022.100063

Wen H, Niu X, Hu L, Sun N, Zhao R, Wang Q et al. Dietary copper intake and risk of myocardial infarction in US adults: A propensity score-matched analysis. Frontiers in Cardiovascular Medicine. 2022 Nov; 9: 942000. doi: 10.3389/fcvm.2022.942000. DOI: https://doi.org/10.3389/fcvm.2022.942000

Hameed OM. Estimation of some Trace Elements in the Sera of People with Myocardial Infarction Disease. InE3S Web of Conferences. 2023; 391: 01124. doi: 10.1051/e3sconf/202339101124. DOI: https://doi.org/10.1051/e3sconf/202339101124

Hussein Challoob M and Mohammed MT. Evaluation of Some Trace Elements and Serum Electrolytes in Patients with Acute Myocardial Infraction. Egyptian Journal of Chemistry. 2023 May; 66(5): 93-7. doi: 10.21608/EJCHEM.2022.141245.6172. DOI: https://doi.org/10.21608/ejchem.2022.141245.6172

Nowicki GJ, Ślusarska B, Prystupa A, Blicharska E, Adamczuk A, Czernecki T et al. Assessment of Concentrations of Heavy Metals (Cu, Zn, Mn, Co, and Fe) in Postmyocardial Infarction Patients and Patients Free from Cardiovascular Event and Their Relationship with the Occurrence of Myocardial Infarction. 2021 Jan; 2021: 9546358. doi: 10.1155/2021/9546358. DOI: https://doi.org/10.1155/2021/9546358

Yang S, Li Y, Zhou L, Wang X, Liu L, Wu M. Copper homeostasis and cuproptosis in atherosclerosis: metabolism, mechanisms and potential therapeutic strategies. Cell Death Discovery. 2024 Jan; 10(1): 25. doi: 10.1038/s41420-023-01796-1. DOI: https://doi.org/10.1038/s41420-023-01796-1

Tarantino G, Porcu C, Arciello M, Andreozzi P, Balsano C. Prediction of carotid intima-media thickness in obese patients with low prevalence of comorbidities by serum copper bioavailability. Journal of Gastroenterology and Hepatology. 2018 Aug; 33(8): 1511-7. doi: 10.1111/jgh.14104. DOI: https://doi.org/10.1111/jgh.14104

Begum S, Sultana I, Faysal MR, Alam S, Tasnim J, Akter T et al. Study of Changes in Serum Copper Level in Patients with Acute Myocardial Infarction. Mymensingh Medical Journal. 2023 Jan; 32(1): 39-43.

Meng JB, Hu MH, Zhang M, Hu GP, Zhang W, Hu SJ. The correlation between whole blood copper (Cu), zinc (Zn) levels and Cu/Zn ratio and sepsis-induced left ventricular systolic dysfunction (SILVSD) in patients with septic shock: a single-center prospective observational study. International Journal of General Medicine. 2021 Oct; 27: 7219-34. doi: 10.2147/IJGM.S335348. DOI: https://doi.org/10.2147/IJGM.S335348

Bayır A, Kara H, Kıyıcı A, Öztürk B, Akyürek F. Levels of selenium, zinc, copper, and cardiac troponin I in serum of patients with acute coronary syndrome. Biological Trace Element Research. 2013 Sep; 154: 352-6. doi: 10.1007/s12011-013-9754-0. DOI: https://doi.org/10.1007/s12011-013-9754-0

Chen A, Li G, Liu Y. Association between copper levels and myocardial infarction: a meta-analysis. Inhalation Toxicology. 2015 Apr; 27(5): 237-46. doi: 10.3109/08958378.2015.1030480. DOI: https://doi.org/10.3109/08958378.2015.1030480

Munoz-Bravo C, Soler-Iborte E, Lozano-Lorca M, Kouiti M, González-Palacios Torres C, Barrios-Rodriguez R et al. Serum copper levels and risk of major adverse cardiovascular events: a systematic review and meta-analysis. Frontiers in Cardiovascular Medicine. 2023 Jun; 10: 1217748. doi: 10.3389/fcvm.2023.1217748. DOI: https://doi.org/10.3389/fcvm.2023.1217748

Ghayour-Mobarhan M, Shapouri-Moghaddam A, Azimi-Nezhad M, Esmaeili H, Parizadeh SM, Safarian M et al. The relationship between established coronary risk factors and serum copper and zinc concentrations in a large Persian cohort. Journal of Trace Elements in Medicine and Biology. 2009 Jul; 23(3): 167-75. doi: 10.1016/j.jtemb.2009.03.006. DOI: https://doi.org/10.1016/j.jtemb.2009.03.006

Andersen KK, Andersen ZJ, Olsen TS. Age-and gender-specific prevalence of cardiovascular risk factors in 40 102 patients with first-ever ischemic stroke: A Nationwide Danish Study. Stroke. 2010 Dec; 41(12): 2768-74. doi: 10.1161/STROKEAHA.110.595785. DOI: https://doi.org/10.1161/STROKEAHA.110.595785

Wang Y, Li Y, Liu X, Zhang H, Abdulai T, Tu R et al. Prevalence and influencing factors of coronary heart disease and stroke in Chinese rural adults: the Henan rural cohort study. Frontiers in Public Health. 2020 Jan; 7: 411. doi: 10.3389/fpubh.2019.00411. DOI: https://doi.org/10.3389/fpubh.2019.00411

Taghavi S, Naderi N, Amin A, Mobini S, Safavirad A, et al. Serum Copper Level in Patients with Heart Failure and Its Related Factors. Multidiscip Cardio Annal. 2021;12(1):e108015. DOI: https://doi.org/10.5812/mca.108015

Bertaina M, Morici N, Frea S, Garatti L, Briani M, Sorini C et al. Differences between cardiogenic shock related to acute decompensated heart failure and acute myocardial infarction. ESC Heart Failure. 2023 Dec; 10(6): 3472-82. doi: 10.1002/ehf2.14510. DOI: https://doi.org/10.1002/ehf2.14510

Al Khatib M, Kteifan A, Shamiyeh M. A Study of Cardiac Arrhythmias in Patients with Myocardial Infarction (STEMI) During The First 48 Hours in The Intensive Care Unit and Its Relationship with Age, Sex, Site of Infarction And Other Risk Factors. Annals of Medicine and Surgery. 2023 Sep; 85(10): 4824-4829. doi: 10.1097/MS9.0000000000001264. DOI: https://doi.org/10.21203/rs.3.rs-2422279/v1

Varshney AS, Berg D, Palazzolo MG, Bohula EA, Katz JN, Van Diepen S et al. End-Organ Dysfunction Differs in Patients With Heart Failure-Related vs. Acute Myocardial Infarction-Related Cardiogenic Shock. Circulation. 2022 Nov; 146(1): A11098-. doi: 10.1161/circ.146.suppl_1.11098. DOI: https://doi.org/10.1161/circ.146.suppl_1.11098

Sinha SS, Rosner CM, Tehrani BN, Maini A, Truesdell AG, Lee SB et al. Cardiogenic shock from heart failure versus acute myocardial infarction: clinical characteristics, hospital course, and 1-year outcomes. Circulation: Heart Failure. 2022 Jun; 15(6): e009279. doi: 10.1161/Circheartfailure.121.009279. DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.121.009279

Sawano S, Sakakura K, Taniguchi Y, Yamamoto K, Tsukui T, Seguchi M et al. Outcomes of patients with acute myocardial infarction who recovered from severe in-hospital complications. The American Journal of Cardiology. 2020 Nov; 135: 24-31. doi: 10.1016/j.amjcard.2020.08.031. DOI: https://doi.org/10.1016/j.amjcard.2020.08.031

Sanmartín-Fernández M, Raposeiras-Roubín S, Anguita-Sánchez M, Marín F, García-Márquez M, Fernández-Pérez C et al. In-hospital outcomes of mechanical complications in acute myocardial infarction: Analysis from a nationwide Spanish database. Cardiology Journal. 2021; 28(4): 589-97. doi: 10.5603/CJ.a2020.0181. DOI: https://doi.org/10.5603/CJ.a2020.0181

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Published

2024-05-31
CITATION
DOI: 10.54393/pjhs.v5i05.1463
Published: 2024-05-31

How to Cite

Orakzai, S. A., Khattak, M., Muhammad, P., Khan, A., Baloch, F. A., & Rasheed, H. ur. (2024). Comparative Sero-Analysis between Copper Levels and the Risk of Acute Myocardial Infarction in District Nowshera: Copper Levels in Acute Myocardial Infarction Patients. Pakistan Journal of Health Sciences, 5(05), 74–79. https://doi.org/10.54393/pjhs.v5i05.1463

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