Iron expression in the biopsies of patients with different grades of Oral Squamous Cell Carcinoma

Tallat Anwar  Faridi; Ali Junaid Dar; Imrana Tanvir; Bilal Hassan

doi:10.54393/pjhs.v1i01.15

Authors

Tallat Anwar Faridi University Institute of Public health, Faculty of Allied Health Sciences, The UNiversity of Lahore, Lahore, Pakistan
Ali Junaid Dar The University of Lahore, Gujrat Campus, Gujrat, Pakistan
Imrana Tanvir Department of Pathology, Faculty of Medicine in Rabigh, King Abdulaziz University, Kingdom of Saudi Arabia
Bilal Hassan Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v1i01.15

Keywords:

Oral squamous cells carcinoma, Iron expression, Malnutrition, Iron deficiency

Abstract

Oral Squamous Cell Carcinoma (OSCC) is becoming a frequent problem all over the world and its etiological factors are different in different areas of the world. Iron is a pivotal nutrient and its deficiency is considered as malnutrition. The possibility that low iron intake might cause oral cancer needs to be investigated Objective: To evaluate the expression of iron in different grades of oral cancer. Methods: A total of 40 biopsy samples of OSCC were included in this study, comprising of 35% well and moderately differentiated and 25% in poorly differentiated cases.Iron staining was performed on all the cases and routine hematoxylin-eosin staining was also performed. Cases were then assessed by two independent hisptopathologists Results: Increased expression of iron in early stage of cancer was observed, which is well differentiated stage. Moderate expression was observed in moderately differentiated stage and almost no expression was observed in highly advanced stage of cancer which is poorly differentiated stage. Conclusions: According to this study, it has been concluded that there is more prevalence of oral cancer in males than in females because the males of this region are more involve in cigratte smoking and the use of oral drugs like pan, gutka, mishri and other types of chewing drugs. Iron deficiency in the body may lead to OSCC.

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