Spectrum of Clinical Manifestations among Paediatrics and Adult Patients of Idiopathic Thrombocytopenic Purpura Presenting to Tertiary Care Hospital

Clinical Manifestations of Thrombocytopenic Purpura

Abstract

Idiopathic Thrombocytopenia Purpura (ITP), an autoimmune bleeding disorder, affects both children and adults, categorized into acute, persistent or chronic types based on symptom duration. Clinical presentations vary widely, ranging from minor bleeds to severe systemic hemorrhages involving CNS, GIT and genitourinary tract. Objective: To assess clinical manifestations in ITP patients at a Lahore tertiary care Hematology department. Methods: This retrospective cross-sectional study included data from 660 diagnosed ITP patients from January 2020 to December 2022 using consecutive sampling technique at Allama Iqbal Medical College. Data were recorded after taking consent from patients. Results: Mean age was 31.8 ± 12.8 SD, with 10.3% children and 89.7% adults. Patients were categorized based on platelet counts into mild, moderate, and severe groups. Most children (47%) and adults (59.9%) had moderate thrombocytopenia. Common features included bruising in children (67.6%), gum bleeding (77%) in adults of both sexes and menorrhagia (67.9%) in females. Conclusions: ITP affects all ages but predominantly females. Clinical presentation varies, with most cases showing superficial bleeding like bruising, epistaxis, gum bleeding, or menorrhagia in females.