Role of Inflammatory and Prognostic Markers and Its Outcome Among Patients with Pre and Post-Operative Colorectal Carcinoma: Markers and Outcomes in Colorectal Carcinoma

Suhail Raza; Amir Iqbal Memon; Aisha Masroor Bhatti; Hitesh Kumar; . Nayab; Sayed Hashim Iqbal

doi:10.54393/pjhs.v5i07.1760

Authors

Suhail Raza Department of General Surgery, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Amir Iqbal Memon Department of General Surgery, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Aisha Masroor Bhatti Department of General Surgery, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Hitesh Kumar Department of General Surgery, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
. Nayab Department of General Surgery, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Sayed Hashim Iqbal Department of General Surgery, Bacha Khan Medical College, Mardan, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i07.1760

Keywords:

Colorectal Cancer, Inflammatory Biomarkers, Surgical Outcomes

Abstract

Colorectal carcinoma is a significant health concern, often presenting with symptoms like bleeding per rectum, mucous discharge, tenesmus, altered bowel habits, and weight loss. This study examines the influence of inflammatory and prognostic markers on the outcomes of patients undergoing per and post-operative treatment for colorectal carcinoma. Objective: To evaluate the role of inflammatory and prognostic markers on the outcomes of patients with per and post-operative colorectal carcinoma. Methods: This cross-sectional study included 112 patients aged 20-60 years, of either gender, with symptoms such as bleeding per rectum, mucous discharge, tenesmus, altered bowel habits, and weight loss for ≥1 month, diagnosed with colorectal cancer regardless of stage and grade. Results: The mean age of the patients was 45.16 ± 10.52 years, with 51.8% males and 48.2% females. Common symptoms included abdominal pain, per rectal bleeding, and weight loss, with 89.3% presenting with anemia. Tumors were located in the colon (84.8%) and rectum (28.6%). Pre-operative markers showed elevated WBC in 59.8%, CRP in 87.5%, decreased serum albumin in 77.7%, raised ESR in 61.6%, ferritin in 65.2%, and LDH in 60.7%. Post-operative markers indicated elevated WBC in 92.9%, CRP in 94.6%, decreased serum albumin in 82.1%, raised ESR in 68.8%, ferritin in 69.6%, and LDH in 73.2%. Complications included wound infection, pneumonia, sepsis, and prolonged hospital stays, with a mortality rate of 3.6%. Conclusions: Serum inflammatory markers significantly influence prognoses and predict adverse outcomes in patients undergoing surgical treatment for colorectal carcinoma.

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