Association of Preterm Delivery with Urinary Tract Infection and Preventive Role of Ceftriaxone: Preventive Role of Ceftriaxone in Urinary Tract Infection

Sumaira Shaheen; Shahnaz Fatima; Shahida Wazir; Lyla Shaheen Naz; Beenish Samreen Hamid; Shubana Tabasum

doi:10.54393/pjhs.v5i08.1870

Authors

Sumaira Shaheen Department of Gynecology and Obstetrics, Khyber Teaching Hospital, Peshawar, Pakistan
Shahnaz Fatima Department of Pharmacology, Sahara Medical College, Narowal, Pakistan
Shahida Wazir Department of Gynecology and Obstetrics, Northwest School of Medicine, Peshawar, Pakistan
Lyla Shaheen Naz Department of Gynecology and Obstetrics, Pakistan Atomic Energy Commission General Hospital, Chashma, Pakistan
Beenish Samreen Hamid Department of Gynecology and Obstetrics, Liaquat Memorial Hospital, Kohat, Pakistan
Shubana Tabasum Mother and Child Healthcare Centre, Pakistan Institute of Medical Sciences, Islamabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i08.1870

Keywords:

Urinary Tract Infection, Preterm Labor, Gestational Age, Ceftriaxone

Abstract

Urinary tract infections (UTIs) are the leading cause of maternal morbidity and poor birth outcomes. Pregnancy changes increase UTI risk. A larger bladder, less tone, and a shift in vaginal flora are changes. Eradicating pathogens in the urogenital tract can lower the risk of infection-related preterm labor by stopping the progression of asymptomatic bacteriuria into a more serious infection. Objective: To determine the association of preterm labor with urinary tract infection and the preventive role of ceftriaxone. Methods: A case-control study was conducted at the Department of Obstetrics and Gynecology, Khyber Teaching Hospital, Peshawar, from 14 December 2021 to 10 June 2022. 130 pregnant women who met the selection criteria were recruited from the hospital's post-delivery wards. The participants were then separated into a case group and a control group. Protocols for treating UTIs in female were followed. Ceftriaxone was administered to the group of participants who were UTI-positive. Results: The mean age of female in the case group was 28.88 ± 7.18 and in the controls group was 28.97 ± 6.85 years. The mean gestational age at delivery in cases was 34.28 ± 1.34 weeks and in controls 39.4 ± 1.11 weeks. There was a significant association between preterm labor and urinary tract infection (p= <0.05). Administration of ceftriaxone reduced the risk of preterm labor (p=0.001). Conclusions: It was concluded that there is a significant correlation between UTIs and premature labor and ceftriaxone plays an important role in reducing preterm delivery of UTI patients.

References

Sameshima H. Definition and diagnosis of preterm labor. Preterm Labor and Delivery. 2020: 7-15. doi: 10.1007/978-981-13-9875-9_2. DOI: https://doi.org/10.1007/978-981-13-9875-9_2

Sergi CM and Sergi CM. Placenta, Abnormal Conception, and Prematurity. Pathology of Childhood and Adolescence: An Illustrated Guide. 2020: 1409-569. doi: 10.1007/978-3-662-59169-7_18. DOI: https://doi.org/10.1007/978-3-662-59169-7_18

Ansaldi Y and de Tejada Weber BM. Urinary tract infections in pregnancy. Clinical Microbiology and Infection. 2022 Aug. doi: 10.1016/j.cmi.2022.08.015. DOI: https://doi.org/10.1016/j.cmi.2022.08.015

Kaur R and Kaur R. Symptoms, risk factors, diagnosis and treatment of urinary tract infections. Postgraduate Medical Journal. 2021 Dec; 97(1154): 803-12. doi: 10.1136/postgradmedj-2020-139090. DOI: https://doi.org/10.1136/postgradmedj-2020-139090

Werter DE, Schneeberger C, Mol BW, De Groot CJ, Pajkrt E, Geerlings SE et al. The risk of preterm birth in low risk pregnant women with urinary tract infections. American Journal of Perinatology. 2023 Oct; 40(14): 1558-66. doi: 10.1055/s-0041-1739289. DOI: https://doi.org/10.1055/s-0041-1739289

Micle O, Antal L, Naghi P, Tica O, Zaha DC, Zdrinca MM, Dobjanchi L, SABĂU M, Muresan M. The prevalence of urinary tract infections in pregnancy and implications on foetal development. Farmacia. 2020 May 1;68(3). doi: 10.31925/farmacia.2020.3.11. DOI: https://doi.org/10.31925/farmacia.2020.3.11

Iqbal F, Naqvi KZ, Ashfaq S, Memon E, Aziz S, Sultan S, Irfan SM. Association of Maternal Lower Urinary Tract Infection with Adverse Fetal Outcome in Terms of Preterm Labor and Low Birth Weight. Journal of The Society of Obstetricians and Gynaecologists of Pakistan. 2017 Jun; 7(1): 33-7.

Werter DE, Kazemier BM, Schneeberger C, Mol BW, de Groot CJ, Geerlings SE et al. Risk indicators for urinary tract infections in low risk pregnancy and the subsequent risk of preterm birth. Antibiotics. 2021 Aug; 10(9): 1055. doi: 10.3390/antibiotics10091055. DOI: https://doi.org/10.3390/antibiotics10091055

Baer RJ, Nidey N, Bandoli G, Chambers BD, Chambers CD, Feuer S et al. Risk of early birth among women with a urinary tract infection: a retrospective cohort study. American Journal of Perinatology Reports. 2021 Jan; 11(01): e5-14. doi: 10.1055/s-0040-1721668. DOI: https://doi.org/10.1055/s-0040-1721668

Sayyoh MA, Hasan LI, Al-dali IM. The relationship between urinary tract infections and preterm labor for pregnant women in Syria. مجلة العلوم الطبية و الصيدلانية. 2022 Jun; 6(2): 84-90. doi: 10.26389/AJSRP.S200921. DOI: https://doi.org/10.26389/AJSRP.S200921

Addisu D, Melkie A, Biru S. Prevalence of Preterm Premature Rupture of Membrane and Its Associated Factors among Pregnant Women Admitted in Debre Tabor General Hospital, North West Ethiopia: Institutional‐Based Cross‐Sectional Study. Obstetrics and Gynecology International. 2020; 2020(1): 4034680. doi: 10.1155/2020/4034680. DOI: https://doi.org/10.1155/2020/4034680

Tedesco RP, Galvão RB, Guida JP, Passini-Júnior R, Lajos GJ, Nomura MLet al. The role of maternal infection in preterm birth: evidence from the Brazilian Multicentre Study on Preterm Birth (EMIP). Clinics. 2020 Mar; 75: e1508. doi: 10.6061/clinics/2020/e1508. DOI: https://doi.org/10.6061/clinics/2020/e1508

de Souza HD, Diório GR, Peres SV, Francisco RP, Galletta MA. Bacterial profile and prevalence of urinary tract infections in pregnant women in Latin America: a systematic review and meta-analysis. BMC Pregnancy and Childbirth. 2023 Nov; 23(1): 774. doi: 10.1186/s12884-023-06060-z. DOI: https://doi.org/10.1186/s12884-023-06060-z

Mlugu EM, Mohamedi JA, Sangeda RZ, Mwambete KD. Prevalence of urinary tract infection and antimicrobial resistance patterns of uropathogens with biofilm forming capacity among outpatients in morogoro, Tanzania: a cross-sectional study. BMC Infectious Diseases. 2023 Oct; 23(1): 660. doi: 10.1186/s12879-023-08641-x. DOI: https://doi.org/10.1186/s12879-023-08641-x

Jalil MB and Al Atbee MY. The prevalence of multiple drug resistance Escherichia coli and Klebsiella pneumoniae isolated from patients with urinary tract infections. Journal of Clinical Laboratory Analysis. 2022 Sep; 36(9): e24619. doi: 10.1002/jcla.24619. DOI: https://doi.org/10.1002/jcla.24619

Alzahrani MA, Ali MS, Anwar S. Bacteria causing urinary tract infections and its antibiotic susceptibility pattern at tertiary hospital in Al-Baha region, Saudi Arabia: a retrospective study. Journal of Pharmacy and BioAllied Sciences. 2020 Oct; 12(4): 449-56. doi: 10.4103/JPBS.JPBS_294_19. DOI: https://doi.org/10.4103/JPBS.JPBS_294_19

Mohamed AH, Sheikh Omar NM, Osman MM, Mohamud HA, Eraslan A, Gur M. Antimicrobial resistance and predisposing factors associated with catheter-associated UTI caused by uropathogens exhibiting multidrug-resistant patterns: a 3-year retrospective study at a tertiary hospital in Mogadishu, Somalia. Tropical Medicine and Infectious Disease. 2022 Mar; 7(3): 42. doi: 10.3390/tropicalmed7030042. DOI: https://doi.org/10.3390/tropicalmed7030042

KS HK, Asina PA, Theckel PG, Divakaran B, Sathar S, Asalatha R et al. Prevalence of multidrug resistant uropathogens isolated from different age groups in South-India: a cross-sectional study. International Journal of Research in Medical Sciences. 2022 Apr;10(4):905. doi: 10.18203/2320-6012.ijrms20220984. DOI: https://doi.org/10.18203/2320-6012.ijrms20220984

Gebremedhin KB, Alemayehu H, Medhin G, Amogne W, Eguale T. Maternal complications and adverse pregnancy outcomes among pregnant women who acquired asymptomatic bacteriuria in Addis Ababa, Ethiopia. BioMed Research International. 2021; 2021(1): 5254997. doi: 10.1155/2021/5254997. DOI: https://doi.org/10.1155/2021/5254997

Bee Bee Hajira HS, Imrana HS, Kamparaj SG. Evaluation of the incidence of pre-eclampsia, preterm labor in association with urinary tract infection (UTI) during pregnancy: An observational study. Medica Innovatica. 2023 Jul; 12(2).