Maternal Biochemical Markers and Risk of Preeclampsia

Biochemical Markers and Preeclampsia Risk

Authors

  • Muhammad Faisal Javaid Department of Biochemistry, Niazi Medical and Dental College, Sargodha, Pakistan
  • Saima Rasheed Department of Biochemistry, Watim Medical and Dental College, Rawalpindi, Pakistan
  • Saddiqa Azmat Department of Obstetrics and Gynecology, Niazi Medical and Dental College, Sargodha, Pakistan
  • Jawad Hussain Qamber Department of Physiology, Sahara Medical College, Narowal, Pakistan
  • Saadia Sajjad Department of Physiology, Abu Umara Medical and Dental College, Lahore, Pakistan
  • Sadia Asghar Department of Obstetrics and Gynecology, Niazi Medical and Dental College, Sargodha, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i08.2084

Keywords:

Biochemical Markers, Preeclampsia, Pregnancy Complications, Risk Assessment, Maternal Health

Abstract

Preeclampsia is a pregnancy disorder associated with a numerous feto-maternal complication. This condition prevails in developing countries, where it is an important reason for feto-maternal morbidity and mortality. Objective: To assess the role of maternal biochemical markers in the development of preeclampsia during pregnancy. Methods: A comparative cross-sectional study was carried out after ethical approval from the Institutional Review Board. The study included 200 participants: 100 patients with preeclampsia and 100 normotensive pregnant women as controls. Preeclampsia was diagnosed based on blood pressure readings above 140/90 mmHg and proteinuria levels exceeding 300 mg/24h. Independentsample t-test was applied to see the differences in both groups in SPSS version 25. Results: Significantly higher mean levels of cholesterol, triglycerides, LDL and Sodium were observed in women with preeclampsia (p <0.0001). Conversely, the mean levels of high-density lipoprotein cholesterol (p= 0.0169), magnesium, calcium and potassium were lower in women with preeclampsia (p <0.0001). Conclusions: Total cholesterol, triglycerides lipid profile and levels of calcium and magnesium were significantly disrupted and showed strong correlations with the severity of the disease. In clinical practice, these biomarkers could facilitate the timely detection of at-risk cases, potentially reducing the rate of feto-maternal complications.

References

Cífková R. Hypertension in pregnancy: a diagnostic and therapeutic overview. High Blood Pressure & Cardiovascular Prevention. 2023 Jul; 30(4): 289-303. doi: 10.1007/s40292-023-00582-5. DOI: https://doi.org/10.1007/s40292-023-00582-5

Patar J and Acharjee N. A Comparative Study of Serum Lipid Profile in Normal Pregnancy and Pregnancy Induced Hypertension. Indian Journal of Public Health Research & Development. 2023 Oct; 14(4). doi: 10.37506/ijphrd. v14i4.19782. DOI: https://doi.org/10.37506/ijphrd.v14i4.19782

Ngene NC and Moodley J. Preventing maternal morbidity and mortality from preeclampsia and eclampsia particularly in low-and middle-income countries. Best Practice & Research Clinical Obstetrics & Gynaecology. 2024 Feb: 102473. doi: 10.1016/j.bpobgyn.2024.102473. DOI: https://doi.org/10.1016/j.bpobgyn.2024.102473

Michalczyk M, Celewicz A, Celewicz M, Woźniakowska-Gondek P, Rzepka R. The role of inflammation in the pathogenesis of preeclampsia. Mediators of Inflammation. 2020 Oct; 2020(1): 3864941. doi: 10.1155/2020/3864941. DOI: https://doi.org/10.1155/2020/3864941

Boeldt DS, Bird IM. Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia. The Journal of Endocrinology. 2017 Jan; 232(1): R27. doi: 10.1530/JOE-16-0340. DOI: https://doi.org/10.1530/JOE-16-0340

Mahajan S, Khan FD, Chauhan N, Singh SB, Kumari A, Agrawal Y. Study of Lipid Profile in Pregnancy Induced Hypertension. European Journal of Cardiovascular Medicine. 2023 Apr; 13(2).

Najeeb MN, Munir U, Sattar N, Yasmin S. Biochemical and Oxidative Biomarkers in Preeclampsia. Age (Years). 2024 Jul; 30(5.78): 31-084. doi: 10.29271/jcpsp.2024.07.780. DOI: https://doi.org/10.29271/jcpsp.2024.07.780

Murmu S and Dwivedi J. Second-trimester maternal serum beta-human chorionic gonadotropin and lipid profile as a predictor of gestational hypertension, preeclampsia, and eclampsia: a prospective observational study. International Journal of Applied and Basic Medical Research. 2020 Jan; 10(1): 49-53. doi: 10.4103/ijabmr.IJABMR_271_19. DOI: https://doi.org/10.4103/ijabmr.IJABMR_271_19

Gera Pk, Persis P, Battula Ss, Bera T, Saripalli S. Estimation of Lipid Profile, Hepatic Enzymes, Malondialdehyde, and Uric Acid in Preeclampsia: Implications for Early Intervention. Journal of Clinical & Diagnostic Research. 2023 Oct; 17(10). doi: 10.7860/JCDR/2023/64842.18636. DOI: https://doi.org/10.7860/JCDR/2023/64842.18636

Versele V, Stas L, Aerenhouts D, Deliens T, Clarys P, Gucciardo L et al. Changes in maternal and paternal body composition during the transition to parenthood (TRANSPARENTS). Obesity. 2023 Jan; 31(1): 225-33. doi: 10.1002/oby.23586. DOI: https://doi.org/10.1002/oby.23586

Mumtaz T, Shahid S, Mustafa N. Analysis of Serum Electrolytes Variation in Onset and Progression of Preeclampsia: Serum Electrolytes Variation in Preeclampsia. Pakistan Journal of Health Sciences. 2023 Sep: 98-102. doi: 10.54393/pjhs. v4i09.1047. DOI: https://doi.org/10.54393/pjhs.v4i09.1047

Uddin SN, Haque M, Barek MA, Chowdhury MN, Das A, Uddin MG et al. Analysis of serum calcium, sodium, potassium, zinc, and iron in patients with pre‐eclampsia in Bangladesh: A case-control study. Health Science Reports. 2023 Feb; 6(2): e1097. doi: 10.1002/hsr2.1097. DOI: https://doi.org/10.1002/hsr2.1097

Saif A, Rizwan W, Durrani H, Iqbal K, Baloch K, Shami N. Frequency of Pregnancy Induced Hypertension in pregnant patients presenting in a tertiary care hospital and Comparison of Serum Lipid Profile in Normotensive and Hypertensive Pregnant Women. Pakistan Journal of Medical Sciences. 2020 Jun; 14(2): 336-9.

Tesfa E, Nibret E, Munshea A. Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis. PLOS One. 2020 Dec; 15(12): e0243538. doi: 10.1371/journal.pone.0243538. DOI: https://doi.org/10.1371/journal.pone.0243538

Yadav S, Agrawal M, Hariharan C, Dewani D, Vadera K, Krishna N. A comparative study of serum lipid profile of women with preeclampsia and normotensive pregnancy. Journal of Datta Meghe Institute of Medical Sciences University. 2018 Apr; 13(2): 83-6. doi: 10.4103/jdmimsu.jdmimsu_70_17. DOI: https://doi.org/10.4103/jdmimsu.jdmimsu_70_17

Li J, Lu J, Wang M, Hu W, Jin N, Li X et al. Predictive value of second-trimester maternal lipid profiling in early-onset pre-eclampsia: a prospective cohort study and nomogram. Frontiers in Medicine. 2021 Dec; 8: 688312. doi: 10.3389/fmed.2021.688312. DOI: https://doi.org/10.3389/fmed.2021.688312

Ebogo-Belobo JT, Bilongo CM, Voufo RA, Atembeh-Noura E, Djabidatou O, Kenfack MT et al. Maternal serum lipids in some women with pre-eclampsia in Yaoundé. Pan African Medical Journal. 2021 May; 39(1). doi: 10.11604/pamj.2021.39.14.22734. DOI: https://doi.org/10.11604/pamj.2021.39.14.22734

Sakarde A, John J, Ahirwar AK, Hardas V. Serum Lipid Profile Parameters as Markers of Oxidative Stress in Preeclampsia-A Case-control Study. National Journal of Laboratory Medicine. 2022; 11: B025-9. doi: 10.7860/NJLM/2022/55717.2620. DOI: https://doi.org/10.7860/NJLM/2022/55717.2620

Ahmed NA, Alzain H, Khalid MO, Abdein A, Eltigani MA, Bakheit KH. Evaluation of Serum Total Calcium, Mg, Na+ and K+ Levels in Sudanese Women with Preeclampsia in Shendi town, River Nile State, North Sudan. World Wide Journal of Multidisciplinary Research and Development. 2020; 6 (1): 24-9.

Aslam F, Hayat I, Zakir FA, Haider SS, Nisa SU, Nisa SU. Comparative analysis of serum calcium and magnesium as a better predictor in cases of mild and severe pre-eclampsia. The Professional Medical Journal. 2020 Aug; 27(08): 1722-7. doi: 10.29309/TPMJ/2020.27.08.4228. DOI: https://doi.org/10.29309/TPMJ/2020.27.08.4228

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Published

2024-08-31
CITATION
DOI: 10.54393/pjhs.v5i08.2084
Published: 2024-08-31

How to Cite

Javaid, M. F., Rasheed, S., Azmat, S., Qamber, J. H., Sajjad, S., & Asghar, S. (2024). Maternal Biochemical Markers and Risk of Preeclampsia: Biochemical Markers and Preeclampsia Risk . Pakistan Journal of Health Sciences, 5(08), 44–48. https://doi.org/10.54393/pjhs.v5i08.2084

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