Prevalence of Metabolic Syndrome in Hepatitis B Virus Infection
Metabolic Syndrome in Hepatitis B Virus Infection
DOI:
https://doi.org/10.54393/pjhs.v5i10.2144Keywords:
Hepatitis B Virus, Metabolic Syndrome, Unhealthy Lifestyle, PrevalenceAbstract
Hepatitis B virus infection is a universal healthcare concern leading to the development of decompensated liver disease, cirrhosis, liver cancer and premature mortality. Likewise, metabolic syndrome caused by unhealthy lifestyle and poor eating habits further increases this risk. Objective: To estimate the prevalence of metabolic syndrome in Hepatitis B virus patients. Methods: This cross-sectional study was executed in the Medical Department of King Edward Medical University, Mayo Hospital, Lahore from 1st August 2022 to 31st July 2023. A total of 200 patients with Hepatitis B virus infection were selected via a non-probability consecutive sampling technique. Waist circumference, blood pressure, serum triglycerides, high-density lipoprotein and blood glucose levels were measured. Patients fulfilling 3 out of 5 criteria were labelled as having metabolic syndrome (MetS). Results: Out of 200 patients of Hepatitis B virus, 153 (76.5%) were male and 47 (23.5%) were female, 136 (68.0%) belonged to the age bracket of 18-40 years and 64 (32.0 %) in the 41-75 years’ age group. The mean age was calculated to be 38.79 ± 5.37 years, the mean BMI was 27.34 ± 5.49 kg/m2 and the duration of Hepatitis B virus infection was 8.84 ± 3.15 months. The prevalence of MetS was observed in 50 (25%) patients of Hepatitis B virus infection. Conclusion: It was concluded that there is a significant proportion of metabolic syndrome among Hepatitis B virus-infected individuals.
References
Chiang CH and Huang KC. Association Between Metabolic Factors and Chronic Hepatitis B Virus Infection. World Journal of Gastroenterology: World Journal of Gastroenterology. 2014 Jun; 20(23): 7213. doi: 10.3748/wjg.v20.i23.7213.
Anwar F, Khan M, Salman M, Ahmad S, Ullah F, Khan J et al. Seroprevalence of Hepatitis B Virus in Human Population of District Buner Khyber Pakhtunkhwa Pakistan. Clinical Epidemiology and Global Health. 2021 Apr; 10: 100688. doi: 10.1016/j.cegh.2020.100688.
Shaikh OA, Aaqil SI, Kumar P, Basit J. Pakistan’s Struggle to Tame Hepatitis: An Ongoing Threat. International Journal of Surgery: Global Health. 2023 Mar; 6(2): e123. doi: 10.1097/GH9.0000000000000123.
Ochani S, Ochani K, Ochani A, Vohra LI, Ochani S, Al Hasibuzzaman M et al. Hepatitis Is Still A Major Health Concern in Pakistan. Annals of Medicine and Surgery. 2023 Nov; 85(11): 5820-2. doi: 10.1097/MS9.0000000000001280.
Wang CC, Tseng TC, Kao JH. Hepatitis B Virus Infection and Metabolic Syndrome: Fact or Fiction? Journal of Gastroenterology and Hepatology. 2015 Jan; 30(1): 14-20. doi: 10.1111/jgh.12700.
Jarčuška P, Janičko M, Kružliak P, Novák M, Veselíny E, Fedačko J et al. Hepatitis B Virus Infection in Patients With Metabolic Syndrome: A Complicated Relationship. Results of A Population-Based Study. European Journal of Internal Medicine. 2014 Mar; 25(3): 286-91. doi: 10.1016/j.ejim.2014.01.006.
Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Current Hypertension Reports. 2018 Feb; 20(2): 1-8. doi: 10.1007/s11906-018-0812-z.
Adil SO, Islam MA, Musa KI, Shafique K. Prevalence of Metabolic Syndrome among Apparently Healthy Adult Population in Pakistan: A Systematic Review and Meta-Analysis. In Healthcare. 2023 Feb; 11(4): 531. doi: 10.3390/healthcare11040531.
Li WenCheng LW, Lee YiYen LY, Chen IChuan CI, Sun Cheng SC, Chiu FengHsiang CF, Chuang ChungHsun CC. Association Between the Hepatitis B and C Viruses and Metabolic Diseases in Patients Stratified by Age. 2013 Sep; 33(8): 1194-1202. doi: 10.1111/liv.12224.
Chen L, Dai J, Xie Q, Wang X, Cai W. Metabolic Risk Factors Are Associated with the Disease Severity and Prognosis of Hepatitis B Virus-Related Acute on Chronic Liver Failure. Gut and Liver. 2022 May; 16(3): 456. doi: 10.5009/gnl210449.
Yan LB, Liao J, Han N, Zhou LY, Wang XE, Wang YJ et al. Association Between Hepatitis B Virus Infection and Metabolic Syndrome in Southwest China: A Cross-Sectional Study. Scientific Reports. 2020 Apr; 10(1): 6738. doi: 10.1038/s41598-020-62609-4.
Wang M, Yan L, Wang J, Jin Y, Zheng ZJ. Global Burden of Hepatitis B Attributable to Modifiable Risk Factors from 1990 to 2019: A Growing Contribution and Its Association with Socioeconomic Status. Globalization and Health. 2023 Mar; 19(1): 23. doi: 10.1186/s12992-023-00922-z.
Shyu YC, Huang TS, Chien CH, Yeh CT, Lin CL, Chien RN. Diabetes Poses a Higher Risk of Hepatocellular Carcinoma and Mortality in Patients with Chronic Hepatitis B: A Population‐Based Cohort Study. Journal of Viral Hepatitis. 2019 Jun; 26(6): 718-26. doi: 10.1111/jvh.13077.
Yip TC, Lee HW, Chan WK, Wong GL, Wong VW. Asian Perspective on NAFLD-Associated HCC. Journal of Hepatology. 2022 Mar; 76(3): 726-34. doi: 10.1016/j.jhep.2021.09.024.
Janičko M, Senajová G, Dražilová S, Veselíny E, Fedačko J, Siegfried L et al. Association Between Metabolic Syndrome and Hepatitis B Virus Infection in the Roma Population in Eastern Slovakia: A Population-Based Study. Central European Journal of Public Health. 2014 Mar; 22(Supplement): S37-42. doi: 10.21101/cejph.a3900.
Chaudhari R, Fouda S, Sainu A, Pappachan JM. Metabolic Complications of Hepatitis C Virus Infection. World Journal of Gastroenterology. 2021 Apr; 27(13): 1267. doi: 10.3748/wjg.v27.i13.1267.
Diao Y, Tang J, Wang X, Deng W, Tang J, You C. Metabolic Syndrome, Nonalcoholic Fatty Liver Disease, and Chronic Hepatitis B: A Narrative Review. Infectious Diseases and Therapy. 2023 Jan; 12(1): 53-66. doi: 10.1007/s40121-022-00725-6.
Zhou Y, Cui Y, Deng H, Yu J. Association Between Hepatitis B Virus Infection and Metabolic Syndrome: A Retrospective Cohort Study in Shanghai, China. BioMed Central Public Health. 2014 Dec; 14: 1-6. doi: 10.1186/1471-2458-14-516.
Wang QX, Xue J, Shi MJ, Xie YB, Xiao HM, Li S et al. Association Between Metabolic Dysfunction-Associated Fatty Liver Disease and the Risk of Cirrhosis in Patients With Chronic Hepatitis B—A Retrospective Cohort Study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2022 Jan; 15: 2311-22. doi: 10.2147/DMSO.S369824.
Patmore LA, Katwaroe WK, van der Spek D, Choi HS, Patel K, Brakenhoff S et al. Association Between the Presence of Metabolic Comorbidities and Liver-Related Events in Patients With Chronic Hepatitis B. Clinical Gastroenterology and Hepatology. 2023 Nov; 21(12): 3089-96. doi: 10.1016/j.cgh.2023.03.024.
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