Prevalence of Hypothyroidism in Non-Alcoholic Fatty Liver Disease (NAFLD) Patients : Hypothyroidism in Non-Alcoholic Fatty Liver Disease (NAFLD) Patients

Mohammad Khalid Hamidi; Tazeen Nazar; Bilal Aziz; Furqan Saeed; Tooba Fatima; Abdul Raffay

doi:10.54393/pjhs.v5i10.2145

Authors

Mohammad Khalid Hamidi East Medical Ward, King Edward Medical University, Mayo Hospital, Lahore, Pakistan
Tazeen Nazar East Medical Ward, King Edward Medical University, Mayo Hospital, Lahore, Pakistan
Bilal Aziz East Medical Ward, King Edward Medical University, Mayo Hospital, Lahore, Pakistan
Furqan Saeed East Medical Ward, King Edward Medical University, Mayo Hospital, Lahore, Pakistan
Tooba Fatima East Medical Ward, King Edward Medical University, Mayo Hospital, Lahore, Pakistan
Abdul Raffay Department of Obstetrician and Gynecologist, Rahbar Medical and Dental College, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i10.2145

Keywords:

Hypothyroidism, Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus

Abstract

Non-alcoholic fatty liver disease is a leading cause of chronic liver disease and has a high prevalence globally. The principal causes range from obesity, hypertriglyceridemia, diabetes mellitus and other endocrinopathies to drugs and certain metabolic disorders. Hypothyroidism associated with non-alcoholic fatty liver disease has raised concerns over recent years but there is limited substantive data to support this evidence. Objective: To ascertain the existing prevalence of hypothyroidism in non-alcoholic fatty liver disease patients presenting to a tertiary care hospital. Methods: It was a descriptive cross-sectional study that was executed in the Medical Department of King Edward Medical University, Mayo Hospital, Lahore from 30^th July 2022 to 29^th July 2023. A total of 215 patients with diagnosed non-alcoholic fatty liver disease on ultrasound were enrolled after taking informed consent and their Thyroid profile i.e., measurement of serum thyroid stimulating hormone, free tri-iodothyronine and free thyroxine was done. Results: From a total of 215 patients, 7 (3.3 %) belonged to the age bracket of 20-40 years and 208 (96.7 %) in the age range of 41-60 years with a female preponderance of 118 (54.9%) and male 97 (45.1%). Mean age was reported to be 50.79 ± 3.95 years and BMI was 23.09 ± 3.93 kg/m². The overall prevalence of hypothyroidism was reported in 42 (19.5%) patients. Conclusion: It was concluded that there is a high prevalence (19.5%) of hypothyroidism in patients with non-alcoholic fatty liver disease.

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