Neuropharmacology of Fisetin as a Senotherapeutic Agent: Investigating Its Role in Neurodegeneration and Brain Aging: Fisetin in Neurodegeneration and Aging

Sidra Javaid; Abeer Memon; Binish Anwar; Zarafshan Bader; Ayesha Aftab; Fouzia Perveen; Ehsan Ul Haq

doi:10.54393/pjhs.v5i11.2399

Authors

Sidra Javaid Department of Internal Medicine, Services Hospital Lahore, Lahore, Pakistan
Abeer Memon Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Binish Anwar Department of Pharmacology, Shalamar Medical and Dental College, Lahore, Pakistan
Zarafshan Bader Department of Pharmacology, Foundation University, Islamabad, Pakistan
Ayesha Aftab Department of Pharmacology, Al Nafees Medical College and Hospital, Islamabad, Pakistan
Fouzia Perveen Department of Pharmacology, Sharif Medical and Dental College, Lahore, Pakistan
Ehsan Ul Haq Institute of Allied Health Sciences, University of Health Sciences, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i11.2399

Keywords:

Fisetin, Neuroprotection, Neurodegeneration, Brain Aging, Cellular Senescence

Abstract

Fisetin, a flavonoid in various fruits and vegetables, has emerged as a promising chemotherapeutic agent with potential neuroprotective effects, particularly in neurodegeneration and brain aging. Objective: To explore the role of fisetin in mitigating age-related neuronal damage by targeting oxidative stress, inflammation, and cellular senescence, common contributors to neurodegenerative diseases such as Alzheimer's and Parkinson's. Methods: Following PRISMA guidelines, relevant studies were sourced from ScienceDirect, Google Scholar, and PubMed, spanning publications between April 2014 and August 2024. One website was also used to retrieve studies, i.e., Frontiers. Fisetin's mechanism of action includes modulating key pathways, such as the inhibition of inflammatory markers, reduction of Reactive Oxygen Species (ROS), and protection against neuronal apoptosis. Results: Studies conducted on various animal models and human-derived neurodegenerative cell lines reveal its potential to improve cognitive function and reduce the progression of age-related brain disorders. Conclusions: Fisetin's ability to selectively target senescent cells, reduce neuroinflammation, and enhance synaptic function positions it as a potential therapeutic for brain aging. Future research focusing on clinical trials and dosing optimization was crucial to establishing fisetin as a viable treatment for neurodegenerative conditions and cognitive decline associated with aging.

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