FIB 4 Score (Liver Fibrosis) and Attending Level of Vitamin D in Chronic Hepatitis C Patients

FIB 4 Score (Liver Fibrosis)

Authors

  • Tariq Sami Baqai Medical University Hospital, Karachi, Pakistan
  • Karim Kammeruddin Baqai Medical University Hospital, Karachi, Pakistan
  • Muhammad Imran Kalsoom Bai Valika Social Security SITE Hospital, Karachi, Pakistan
  • Mahboob Ali Horizon School of Nursing and Health Sciences, Karachi, Pakistan
  • Nadia Rahman Ziauddin University, Karachi, Pakistan
  • Syed Abdul Waheed Fatima Jinnah Institute of Chest Disease, Quetta, Pakistan
  • Javed Ali Suvastu School of Nursing and Health Sciences, Karachi, Pakistan
  • Afsha Bibi Horizon School of Nursing and Health Sciences, Karachi, Pakistan
  • Abdul Latif Baqai Medical University Hospital, Karachi, Pakistan
  • Saeed Mazher Baqai Medical University Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v4i06.811

Keywords:

FIB 4 Score, Liver Fibrosis, Level, Vitamin D, Chronic, Hepatitis C, Patients

Abstract

Millions of people around the world are affected by chronic hepatitis C (HCV), which is a global health issue. It is a major contributor to chronic liver conditions such as cirrhosis, hepatocellular carcinoma, and liver fibrosis. For optimal therapy and intervention, prompt identification of liver fibrosis is essential. The rate of hepatic fibrosis progression in HCV-infected patients varies substantially. Objective: To evaluate the vitamin D level and liver fibrosis degree by non-invasive Fib 4 score among chronic hepatitis patients. Methods: This Cross-sectional study was conducted at a tertiary care hospital in Karachi, Pakistan, from August 2020 to September 2022. 65 participants were recruited through a non-probability sampling technique. Results: Study findings show that 21.9% of the patients have low risk for advanced fibrosis, whereas 9.2% have an Intermediate risk for advanced fibrosis, and 69.2% have a high risk for advanced fibrosis. Moreover, findings also revealed that among 65 patients, 66.2% have a deficient amount of Vitamin D, whereas 16.9% have an insufficient amount of Vitamin D level and 16.9% have a sufficient amount of vitamin D. Furthermore, the findings also showed significant association based on p-value (0.001) between Age and Fib4 score of the participant. Conclusions: In conclusion, the study revealed that a significant proportion of chronic hepatitis C patients were at high risk for advanced fibrosis, while vitamin D deficiency/ insufficiency were prevalent among the majority of the patients.

References

Craxì A, Laffi G, Zignego AL. Hepatitis C virus (HCV) infection: a systemic disease. Molecular Aspects of Medicine. 2008 Feb; 29(1-2): 85-95. doi: 10.1016/j.mam.2007.09.017. DOI: https://doi.org/10.1016/j.mam.2007.09.017

Cheemerla S and Balakrishnan M. Global epidemiology of chronic liver disease. Clinical Liver Disease. 2021 May; 17(5): 365. doi: 10.1002/cld.1061. DOI: https://doi.org/10.1002/cld.1061

Fallatah H. Noninvasive biomarkers of liver fibrosis: An overview. Advances in Hepatology. 2014 Apr; 2014: 1-15. doi: 10.1155/2014/357287. DOI: https://doi.org/10.1155/2014/357287

Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-Gentilucci U, et al. Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease. World Journal of Gastroenterology. 2017 May; 23(19): 3407. doi: 10.3748/wjg.v23.i19.3407. DOI: https://doi.org/10.3748/wjg.v23.i19.3407

Tamaki N, Kurosaki M, Tanaka K, Suzuki Y, Hoshioka Y, Kato T, et al. Noninvasive estimation of fibrosis progression overtime using the FIB‐4 index in chronic hepatitis C. Journal of Viral Hepatitis. 2013 May; 20(1): 72-6. doi: 10.1111/j.1365-2893.2012.01635.x. DOI: https://doi.org/10.1111/j.1365-2893.2012.01635.x

von Websky K, Hasan AA, Reichetzeder C, Tsuprykov O, Hocher B. Impact of vitamin D on pregnancy-related disorders and on offspring outcome. The Journal of steroid Biochemistry and Molecular Biology. 2018 Jun; 180: 51-64. doi: 10.1016/j.jsbmb.2017.11.008. DOI: https://doi.org/10.1016/j.jsbmb.2017.11.008

Udomsinprasert W and Jittikoon J. Vitamin D and liver fibrosis: Molecular mechanisms and clinical studies. Biomedicine & Pharmacotherapy. 2019 Jan; 109: 1351-60. doi: 10.1016/j.biopha.2018.10.140. DOI: https://doi.org/10.1016/j.biopha.2018.10.140

Hoan NX, Van Tong H, Meyer CG, Velavan TP. Vitamin D deficiency and hepatitis viruses-associated liver diseases: a literature review. World Journal of Gastroenterology. 2018 Jan; 24(4): 445. doi: 10.3748/wjg.v24.i4.445. DOI: https://doi.org/10.3748/wjg.v24.i4.445

Beilfuss A, Sowa JP, Sydor S, Beste M, Bechmann LP, Schlattjan M, et al. Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently. Gut. 2015 May; 64(5): 791-9. doi: 10.1136/gutjnl-2014-307024. DOI: https://doi.org/10.1136/gutjnl-2014-307024

de Lucca Schiavon L, Narciso-Schiavon JL, de Carvalho-Filho RJ. Non-invasive diagnosis of liver fibrosis in chronic hepatitis C. World journal of gastroenterology: WJG. 2014 Mar; 20(11): 2854. doi: 10.3748/wjg.v20.i11.2854. DOI: https://doi.org/10.3748/wjg.v20.i11.2854

Martinez SM, Crespo G, Navasa M, Forns X. Noninvasive assessment of liver fibrosis. Hepatology. 2011 Jan; 53(1): 325-35. doi: 10.1002/hep.24013. DOI: https://doi.org/10.1002/hep.24013

Iruzubieta P, Terán Á, Crespo J, Fábrega E. Vitamin D deficiency in chronic liver disease. World Journal of Hepatology. 2014 Dec; 6(12): 901. doi: 10.4254/wjh.v6.i12.901. DOI: https://doi.org/10.4254/wjh.v6.i12.901

Fisher L and Fisher A. Vitamin D and parathyroid hormone in outpatients with noncholestatic chronic liver disease. Clinical gastroenterology and Hepatology. 2007 Apr; 5(4): 513-20. doi: 10.1016/j.cgh.2006.10.015. DOI: https://doi.org/10.1016/j.cgh.2006.10.015

Luger M, Kruschitz R, Kienbacher C, Traussnigg S, Langer FB, Schindler K, et al. Prevalence of liver fibrosis and its association with non-invasive fibrosis and metabolic markers in morbidly obese patients with vitamin D deficiency. Obesity Surgery. 2016 Oct; 26: 2425-32. doi: 10.1007/s11695-016-2123-2. DOI: https://doi.org/10.1007/s11695-016-2123-2

Arteh J, Narra S, Nair S. Prevalence of vitamin D deficiency in chronic liver disease. Digestive Diseases and Sciences. 2010 Sep; 55: 2624-8. doi: 10.1007/s10620-009-1069-9. DOI: https://doi.org/10.1007/s10620-009-1069-9

Pérez-López FR. Vitamin D and its implications for musculoskeletal health in women: an update. Maturitas. 2007 Oct; 58(2): 117-37. doi: 10.1016/j.maturitas.2007.05.002. DOI: https://doi.org/10.1016/j.maturitas.2007.05.002

Poynard T, Lebray P, Ingiliz P, Varaut A, Varsat B, Ngo Y, et al. Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest). BMC Gastroenterology. 2010 Dec; 10(1): 1-3. doi: 10.1186/1471-230X-10-40. DOI: https://doi.org/10.1186/1471-230X-10-40

Caballería L, Pera G, Arteaga I, Rodríguez L, Alumà A, Morillas RM, et al. High prevalence of liver fibrosis among European adults with unknown liver disease: a population-based study. Clinical Gastroenterology and Hepatology. 2018 Jul; 16(7): 1138-45. doi: 10.1016/j.cgh.2017.12.048. DOI: https://doi.org/10.1016/j.cgh.2017.12.048

Nah EH, Cho S, Kim S, Chu J, Kwon E, Cho HI. Prevalence of liver fibrosis and associated risk factors in the Korean general population: a retrospective cross-sectional study. BMJ Open. 2021 Mar; 11(3): e046529. doi: 10.1136/bmjopen-2020-046529. DOI: https://doi.org/10.1136/bmjopen-2020-046529

Ebadi M, Ip S, Bhanji RA, Montano-Loza AJ. Effect of coffee consumption on non-alcoholic fatty liver disease incidence, prevalence and risk of significant liver fibrosis: Systematic review with meta-analysis of observational studies. Nutrients. 2021 Aug; 13(9): 3042. doi: 10.3390/nu13093042. DOI: https://doi.org/10.3390/nu13093042

Downloads

Published

2023-06-30
CITATION
DOI: 10.54393/pjhs.v4i06.811
Published: 2023-06-30

How to Cite

Sami, T. ., Kammeruddin, K. ., Imran, M. ., Ali, M. ., Rahman, N. ., Waheed, S. A. ., Ali, J. ., Bibi, A. ., Latif, A. ., & Mazher, S. . (2023). FIB 4 Score (Liver Fibrosis) and Attending Level of Vitamin D in Chronic Hepatitis C Patients: FIB 4 Score (Liver Fibrosis). Pakistan Journal of Health Sciences, 4(06), 165–169. https://doi.org/10.54393/pjhs.v4i06.811

Issue

Section

Original Article

Plaudit

Most read articles by the same author(s)

1 2 3 > >>