Prevalence of Hyperuricemia In Acute Ischemic Stroke Patients: A Cross-Sectional Study
Hyperuricemia In Acute Ischemic Stroke Patients
DOI:
https://doi.org/10.54393/pjhs.v4i10.957Keywords:
Hyperuricemia, Acute Ischemia, StrokeAbstract
Ischemic stroke is responsible for a significant proportion of stroke cases, with stroke being a major contributor to mortality and morbidity on a global scale. Objective: To check the relation of hyperuricemia with stroke. Methods: A cross-sectional study was carried out in the Jinnah Post-graduate Medical Center's Medicine ward more than six months after the acceptance of the synopsis. This study was conducted between 2020 and 2021. The sample size for the study was determined to be at least 94. Non-probability consecutive sampling was employed to select patients aged >20 years, of either sex, who were diagnosed with acute ischemic stroke. Patients with ischemic stroke due to a known thrombophilic condition and those with hyperuricemia secondary to high cell turnover from cancer chemotherapy were excluded from the study. The frequencies and percentages were collected and calculated and chi-square was used to evaluate the significance. The p-value of <0.005 was considered significant. Results: We enrolled 94 patients in total. Table 1 shows the demographics of the patients who presented to the hospital. The most common age group was >60 years and the majority of the patients were male (61.7%). The 51 (54.2%) patients have a BMI >25. 65 (69.1%) of the patients had diabetes. The relationship between the patients with hyperuricemia with the male gender, hypertensive patients, and patients who smoke with a p-value of <0.001. Conclusions: In conclusion, hyperuricemia appears to be prevalent in acute ischemic stroke patients, especially among the elderly population.
References
Sarfo FS, Akassi J, Antwi NK, Obese V, Adamu S, Akpalu A, et al. Highly prevalent hyperuricaemia is associated with adverse clinical outcomes among Ghanaian stroke patients: An observational prospective study. Ghana Medical Journal. 2015 Sep; 49(3): 165-72. doi: 10.4314/gmj.v49i3.7. DOI: https://doi.org/10.4314/gmj.v49i3.7
Mapoure YN, Ayeah CM, Ba H, Hentchoya R, Luma HN. The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans. Journal of Stroke and Cerebrovascular Diseases. 2018 Mar; 27(3): 783-92. doi: 10.1016/j.jstrokecerebrovasdis. 2017.10.006. DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.10.006
Zhao J, Chen H, Liu N, Chen J, Gu Y, Chen J, et al. Role of hyper homocysteinemia and hyperuricemia in pathogenesis of atherosclerosis. Journal of Stroke and Cerebrovascular Diseases. 2017 Dec; 26(12): 2695-9. doi: 10.1016/j.jstrokecerebrovasdis.2016. 10.012. DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.10.012
Jensson O, Gudmundsson G, Arnason A, Blöndal H, Petursdottir I, Thorsteinsson L, et al. Hereditary cystatin C (γ-trace) amyloid angiopathy of the CNS causing cerebral hemorrhage. Acta Neurologica Scandinavica. 1987 Aug; 76(2): 102-14. doi: 10.1111/ j.1600-0404.1987.tb03553.x. DOI: https://doi.org/10.1111/j.1600-0404.1987.tb03553.x
Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Annals of Internal Medicine. 1999 Jul; 131(1): 7-13. doi: 10.7326/0003-4819-131-1-199907060-00003. DOI: https://doi.org/10.7326/0003-4819-131-1-199907060-00003
Derdeyn CP, Khosla A, Videen TO, Fritsch SM, Carpenter DL, Grubb RL Jr. Severe hemodynamic impairment, and border zoneregion infarction. Radiology. 2001 Jul; 220(1): 195-201. doi: 10.1148/radiology.220.1.r01jl09195. DOI: https://doi.org/10.1148/radiology.220.1.r01jl09195
Pollanen MS and Deck JH. Directed embolization is an alternate cause of cerebral watershed infarction. Archives of Pathology Laboratory Medicine. 1989 Oct; 113(10): 1139-41.
Waterston JA, Brown MM, Butler P, Swash M. Small deep cerebral infarcts associated with occlusive internal carotid artery disease. A hemodynamic phenomenon? Archives of Neurology. 1990 Sep; 47(9): 953-7. doi: 10.1001/archneur.1990.00530090 023007. DOI: https://doi.org/10.1001/archneur.1990.00530090023007
Tripathi VD and Hussain Z. A study to nd out relationship in between serum uric acid level and stroke. International Journal of Advanced Medicine. 2017 Sep; 4: 1255-9. doi: 10.18203/2349- 3933.am20173661. DOI: https://doi.org/10.18203/2349-3933.ijam20173661
George C and Minter DA. Hyperuricemia. StatPearls Publishing; 2021.
Padda J, Khalid K, Padda S, Boddeti NL, Malhi BS, Nepal R, et al. Hyperuricemia and its association with ischemic stroke. Cureus. 2021 Sep; 13(9): e18172. doi: 10.7759/cureus.18172. DOI: https://doi.org/10.7759/cureus.18172
Arboix A, García-Eroles L, Massons JB, Oliveres M, Comes E. Predictive factors of early seizures after acute cerebrovascular disease. Stroke. 1997 Aug; 28(8): 1590-4. doi: 10.1161/01.STR.28.8.1590. DOI: https://doi.org/10.1161/01.STR.28.8.1590
Karagiannis A, Mikhailidis DP, Tziomalos K, Sileli M, Savvatianos S, Kakaka A, et al. Serum uric acid as an independent predictor of early death after acute stroke. Circulation Journal. 2007 Jul; 71(7): 1120-7. doi: 10.1253/circj.71.1120. DOI: https://doi.org/10.1253/circj.71.1120
Yadav SK, Nepal N, Niroula D. Prevalence of hyperuricemia among people of Morang district of Nepal. Journal of Nobel Medical College. 2014 Mar; 3(1): 16-21. doi: 10.3126/jonmc.v3i1.10048. DOI: https://doi.org/10.3126/jonmc.v3i1.10048
Kasner SE and Grotta JC. Emergency identication and treatment of acute ischemic stroke. Annals of Emergency Medicine. 1997 Nov; 30(5): 642-53. doi: 10.1016/S0196-0644(97)70084-2. DOI: https://doi.org/10.1016/S0196-0644(97)70084-2
Uaratanawong S, Suraamornkul S, Angkeaw S, Uaratanawong R. Prevalence of hyperuricemia in Bangkok population. Clinical Rheumatology. 2011 Jul; 30(7): 887-93. doi: 10.1007/s10067-011-1699-0. DOI: https://doi.org/10.1007/s10067-011-1699-0
Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid to mortality and ischemic heart disease: the NHANES I Epidemiologic Follow-up Study. American Journal of Epidemiology. 1995 Apr; 141(7): 637-44. doi: 10.1093/oxfordjournals.aje.a117479. DOI: https://doi.org/10.1093/oxfordjournals.aje.a117479
Mullins ME, Lev MH, Schellingerhout D, Gonzalez RG, Schaefer PW. Intracranial hemorrhage complicating acute stroke: how common is hemorrhagic stroke on initial head CT scan and how often is initial clinical diagnosis of acute stroke eventually conrmed? AJNR American Journal of Neuroradiology. 2005 Oct; 26(9): 2207-12.
Liu H, Zhang XM, Wang YL, Liu BC. Prevalence of hyperuricemia among Chinese adults: a national cross-sectional survey using multistage, stratied sampling. Journal of Nephrology. 2014 Dec; 27(6): 653-8. doi: 10.1007/s40620-014-0082-z. DOI: https://doi.org/10.1007/s40620-014-0082-z
Smitha CS and Kumar PK. A Study on Serum Uric Acid Level in Acute Ischemic Stroke. European Journal of Molecular & Clinical Medicine. 2022 Apr; 9(3): 2931-6.
Longo-Mbenza B, Luila EL, Mbete P, Vita EK. Is hyperuricemia a risk factor of stroke and coronary heart disease among Africans? International Journal of Cardiology. 1999 Sep; 71(1): 17-22. doi: 10.1016/S0167-5273(99)00097-2. DOI: https://doi.org/10.1016/S0167-5273(99)00097-2
Ahn SH, Lee SH, Kim BJ, Lim KH, Bae SJ, Kim EH, et al. Higher serum uric acid is associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in healthy postmenopausal women. Osteoporosis International. 2013 Dec; 24(12): 2961-70. doi: 10.1007/s00198-013-2377-7. DOI: https://doi.org/10.1007/s00198-013-2377-7
Chiquete E, Ruiz-Sandoval JL, Murillo-Bonilla LM, Arauz A, Orozco-Valera DR, Ochoa-Guzmán A, et al. Serum uric acid and outcome after acute ischemic stroke: PREMIER study. Cerebrovascular Diseases. 2013 Mar; 35(2): 168-74. doi: 10.1159/000346603. DOI: https://doi.org/10.1159/000346603
Fang J and Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA. 2000 May; 283(18): 2404-10. doi: 10.1001/jama.283.18.2404. DOI: https://doi.org/10.1001/jama.283.18.2404
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Pakistan Journal of Health Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments
