Comparative Efficacy of Topical Tacrolimus 0.1% and Clobetasol Propionate 0.05% in the Treatment of Alopecia Areata (AA)

Efficacy of Tacrolimus and Clobetasol Propionate in the Treatment of Alopecia Areata

Authors

  • Danyal Sajjad Department of Dermatology, Combined Military Hospital, Abbottabad, Pakistan
  • Bushra Muzaffar Department of Dermatology, Combined Military Hospital, Abbottabad, Pakistan
  • Muhammad Adeel Siddiqui Department of Dermatology, Combined Military Hospital, Abbottabad, Pakistan
  • Majid Hussain Department of Dermatology, Combined Military Hospital, Abbottabad, Pakistan
  • Sana Aslam Department of Dermatology, Combined Military Hospital, Abbottabad, Pakistan
  • Huma Farid Department of Dermatology, Combined Military Hospital, Abbottabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v4i11.1168

Keywords:

Alopecia Areata, Clobetasol Propionate, Tacrolimus

Abstract

Alopecia areata patients can choose from a variety of therapy methods. Each method has advantages and limitations, and its suitability varies for each patient. The medical usefulness of topical corticosteroids in AA is yet debatable. Objective: To assess the effectiveness of topical tacrolimus 0.1% vs. topical clobetasol propionate 0.05% while treating alopecia areata. Methods: Randomized-controlled trial (Double blind) conducted in Dermatology Department, CMH-Abbottabad, from November 2022 to April 2023. The seventy (70) patients with alopecia areata who attended to OPD of CMH Abbottabad between the ages of 20 and 50 were included. The non-probability consecutive sampling method was used. For up to 3 months, patients in Group A used clobetasol propionate 0.05% twice daily, while patients in Group B used topical tacrolimus 0.1% twice daily. Patients were evaluated at the start of each session, four weeks later, eight weeks later, and twelve weeks later. The SALT score was used to estimate hair loss at presentation and during the 3-month follow-up. The degree of response has been characterized by following hair re-growth as excellent (>75%), marked (51-75%), moderate (26-50%), or mild (25%). A p-value of <0.05 was considered significant.  Results: When the efficacy was compared, 26 (74.3%) patients in group-A (mean age 35.23+7.87 years) shown excellent response, while 14 (40%) patients in group-B (mean age 34.29+7.87 years) with significant p-value was 0.028. Conclusions: Clobetasol propionate 0.05% was more efficacious as a therapy choice for stimulating hair re-growth in patients. 

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Published

2023-11-30
CITATION
DOI: 10.54393/pjhs.v4i11.1168
Published: 2023-11-30

How to Cite

Sajjad, D., Muzaffar, B., Siddiqui, M. A., Hussain, M., Aslam, S., & Farid, H. (2023). Comparative Efficacy of Topical Tacrolimus 0.1% and Clobetasol Propionate 0.05% in the Treatment of Alopecia Areata (AA) : Efficacy of Tacrolimus and Clobetasol Propionate in the Treatment of Alopecia Areata . Pakistan Journal of Health Sciences, 4(11), 77–80. https://doi.org/10.54393/pjhs.v4i11.1168

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