Frequency of Urinary Tract Infection among Neonates with Persistent Jaundice at Lady Reading Hospital, Peshawar
Frequency of Urinary Tract Infection among Neonates
DOI:
https://doi.org/10.54393/pjhs.v5i01.1221Keywords:
Neonates, Persistent Jaundice, Hyperbilirubinemia, Urinary Tract InfectionAbstract
Jaundice refers to yellow-orange discoloration of the skin and sclera, resulting from an excessive accumulation of bilirubin in the dermis and mucous membranes. Indirect neonatal hyperbilirubinemia is a prevalent and frequent etiology of jaundice, leading to the hospitalization of neonates in healthcare institutions worldwide. Objective: To determine the frequency of urinary tract infection among neonates with prolonged jaundice. Methods: The present study, a cross-sectional design, was carried out at the Department of Pediatrics, Lady Reading Hospital, Peshawar, from June 20th to December 20th, 2022. The study consisted of 87 infants, encompassing both genders, who presented with persistent jaundice. Two samples of clean urine were collected from neonates, with a time interval of many minimums of two hours between each collection. These samples were then sent to the hospital laboratory for diagnosing urinary tract infection. Results: The age range of participant neonates in this study ranged from 14 to 28 days, with a mean age of 20.597±4.50 days. The mean duration of complaint was also 18.20±4.077 days, and the mean weight was 2.855±0.27 Kg. The proportion of male patients was 58.6%, while the proportion of female patients was 41.4%. Among these 11.5% were found to have urinary tract infection. Conclusions: It is concluded that significant number (11.5%) of patients with persistent jaundice has urinary tract infection. It is likely a potential etiological factor contributing to neonatal unexplained prolonged indirect hyperbilirubinemia.
References
Shitran RF and Abed MY. Risk factors and outcomes of neonatal jaundice at Al-Ramadi teaching hospital for maternity and childhood. Annals of Tropical Medicine and Public Health. 2020; 23(12): 231. doi: 10.36295/ASRO.2020.231228. DOI: https://doi.org/10.36295/ASRO.2020.231228
Pan DH and Rivas Y. Jaundice: newborn to age 2 months. Pediatrics in Review. 2017 Nov; 38(11): 499-510. doi: 10.1542/pir.2015-0132. DOI: https://doi.org/10.1542/pir.2015-0132
Ullah S, Rahman K, Hedayati M. Hyperbilirubinemia in neonates: types, causes, clinical examinations, preventive measures and treatments: a narrative review article. Iranian Journal of Public Health. 2016 May; 45(5): 558.
Karmazyn BK, Alazraki AL, Anupindi SA, Dempsey ME, Dillman JR, Dorfman SR et al. ACR appropriateness criteria® urinary tract infection—child. Journal of the American College of Radiology. 2017 May; 14(5): S362-71. doi: 10.1016/j.jacr.2017.02.028. DOI: https://doi.org/10.1016/j.jacr.2017.02.028
Korbel L, Howell M, Spencer JD. The clinical diagnosis and management of urinary tract infections in children and adolescents. Paediatrics and International Child Health. 2017 Oct; 37(4): 273-9. doi: 10.1080/20469047.2017.1382046. DOI: https://doi.org/10.1080/20469047.2017.1382046
Balighian E and Burke M. Urinary Tract Infections in Children. Pediatric Reviews. 2018 Jan; 39(1): 3-12. doi: 10.1542/pir.2017-0007. PMID: 29292282. doi: 10.1542/pir.2017-0007. DOI: https://doi.org/10.1542/pir.2017-0007
Leung AK, Wong AH, Leung AA, Hon KL. Urinary tract infection in children. Recent Patents on Inflammation & Allergy Drug Discovery. 2019 May; 13(1): 2-18. doi: 10.2174/1872213X13666181228154940. DOI: https://doi.org/10.2174/1872213X13666181228154940
Weng YH, Cheng SW, Yang CY, Chiu YW. Risk assessment of prolonged jaundice in infants at one month of age: A prospective cohort study. Scientific Reports. 2018 Oct; 8(1): 14824. doi: 10.1038/s41598-018-33249-6. DOI: https://doi.org/10.1038/s41598-018-33249-6
Pashapour N, Nikibahksh AA, GOL MS. Urinary tract infection in term neonates with prolonged jaundice. Urology Journal. 2007; 4(2): 91-4.
Harb A, Yassine V, Ghssein G, Salami A, Fakih H. Prevalence and Clinical Significance of Urinary Tract Infection among Neonates Presenting with Unexplained Hyperbilirubinemia in Lebanon: a Retrospective Study. Infection & Chemotherapy. 2023 Jun; 55(2): 194. doi: 10.3947/ic.2022.0117. DOI: https://doi.org/10.3947/ic.2022.0117
Almohayya TS, Alshabanah RF, Alahmari EM, Almanie NI, Almanie RA, AlJelban AS et al. Incidence and Risk Factors for Neonatal Jaundice among Neonates with Urinary Tract Infection in Abha-Saudi Arabia. The Egyptian Journal of Hospital Medicine. 2017 Apr; 67(2): 692-6. doi: 10.12816/0037823. DOI: https://doi.org/10.12816/0037823
Shahian M, Rashtian P, Kalani M. Unexplained neonatal jaundice as an early diagnostic sign of urinary tract infection. International Journal of Infectious Diseases. 2012 Jul; 16(7): e487-90. doi: 10.1016/j.ijid.2012.02.011. DOI: https://doi.org/10.1016/j.ijid.2012.02.011
Kasap B, Soylu A, Kavukçu S. Relation between hyperbilirubinemia and urinary tract infections in the neonatal period. Journal of Nephrology and Therapeutics. 2014; 11: 009. doi: 10.4172/2161-0959.S11-009. DOI: https://doi.org/10.4172/2161-0959.S11-009
Ahmed SM, Jan P, Zaman S, Kakar SU, Shah SA, Ayub A. Frequency of Urinary Tract Infection (UTI) in Neonates Admitted with Indirect Hyperbilirubinemia. Pakistan Journal of Medical & Health Sciences. 2022 Oct; 16(09): 302-. doi: 10.53350/pjmhs22169302. DOI: https://doi.org/10.53350/pjmhs22169302
Boskabadi H, Maamouri G, Kiani MA, Abdollahi A. Evaluation of urinary tract infections following. Journal of Shahrekord University of Medical Sciences. 2010 Jul; 12(2): 95-100.
Hansen TW. The epidemiology of neonatal jaundice. Pediatric Medicine. 2021; 5(18): 18-. doi: 10.21037/pm-21-4. DOI: https://doi.org/10.21037/pm-21-4
Baz AM, El-Agamy OA, Ibrahim AM. Incidence of urinary tract infection in neonates with significant indirect Hyperbilirubinemia of unknown etiology: case-control study. Italian Journal of Pediatrics. 2021 Dec; 47: 1-6. doi: 10.1186/s13052-021-00982-0. DOI: https://doi.org/10.1186/s13052-021-00982-0
Özcan M, Sarici SÜ, Yurdugül Y, Akpinar M, Altun D, Özcan B et al. Association between early idiopathic neonatal jaundice and urinary tract infections. Clinical Medicine Insights: Pediatrics. 2017 Mar; 11: 1179556517701118. doi: 10.1177/1179556517701118. DOI: https://doi.org/10.1177/1179556517701118
Abdelrheem SS, Aly HM, Diab F, Maebed A, Osman AO, Mhsb AH, Alaswad NK et al. Prediction of Urinary Tract Infection in Neonates with Unexplained Indirect Hyperbilirubinemia. Open Access Macedonian Journal of Medical Sciences. 2022 Jun; 10(E): 1153-60. doi: 10.3889/oamjms.2022.9933. DOI: https://doi.org/10.3889/oamjms.2022.9933
Deger I, Ertuğrul S, Yolbaş I, Tekin R. Evaluation of urinary tract infections in neonatal indirect hyperbilirubinemia. Minerva Pediatrics. 2022 Oct; 74(5): 562-7. doi: 10.23736/S2724-5276.21.06295-9. DOI: https://doi.org/10.23736/S2724-5276.21.06295-9
Tawfeek MA, Ellahony DM, Abdulhadi IA. Study of some factors associated with prolonged neonatal jaundice. Menoufia Medical Journal. 2020 Jan; 33(1): 167. doi: 10.4103/mmj.mmj_279_18. DOI: https://doi.org/10.4103/mmj.mmj_279_18
Aygün E, Ertürk EY, Sayman ÖA, Tiryaki FK. Evaluation of Etiological, Clinical and Laboratory Findings in Infants with Prolonged Jaundice. Age. 2020; 3: 3-3. doi: 10.26717/BJSTR.2020.31.005151. DOI: https://doi.org/10.26717/BJSTR.2020.31.005151
Chen LJ, Chen PJ, Yang SF, Chen JY. Causative organisms and antimicrobial susceptibility in jaundiced infants with significant bacteriuria. Journal of the Chinese Medical Association. 2022 Apr; 85(4): 514-8. doi: 10.1097/JCMA.0000000000000698. DOI: https://doi.org/10.1097/JCMA.0000000000000698
Sheaff E, Schindler N, Brightwell A. 1420 A retrospective study of urinalysis in the prolonged jaundice clinic. 2020; 106(1). doi: 10.1136/archdischild-2021-rcpch.632. DOI: https://doi.org/10.1136/archdischild-2021-rcpch.632
Tzimenatos L, Mahajan P, Dayan PS, Vitale M, Linakis JG, Blumberg S et al. Accuracy of the urinalysis for urinary tract infections in febrile infants 60 days and younger. Pediatrics. 2018 Feb; 141(2). doi: 10.1542/peds.2017-3068. DOI: https://doi.org/10.1542/peds.2017-3068
Lo YC, Tsai WJ, Tsao PC, Lee YS. Relationship between infectious screening and early unconjugated hyperbilirubinemia in well-appearing neonates. Journal of the Chinese Medical Association. 2020 Apr; 83(4): 406-10. doi: 10.1097/JCMA.0000000000000290. DOI: https://doi.org/10.1097/JCMA.0000000000000290
Moyo GP, Um SS, Awa HD, Mah E, Chiabi A. The pathophysiology of neonatal jaundice in urosepsis is complex with mixed bilirubin. Journal of Pediatrics and Neonatal Care. 2022; 12(2): 68-70. doi: 10.15406/jpnc.2022.12.00458. DOI: https://doi.org/10.15406/jpnc.2022.12.00458
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