Comparison Between Efficacy of Serial Glycolic Acid Peel with Modified Kligman’s Regimen Vs Modified Kligman’s Regimen Alone in Epidermal Melasma
Glycolic Acid Peel with Modified Kligman’s Regimen Vs Modified Kligman’s Regimen
DOI:
https://doi.org/10.54393/pjhs.v5i03.1284Keywords:
Epidermal Melasma, Modified Kligman's Regimen, Glycolic Acid Peel, MASI ScoreAbstract
The background of melasma involves its psychological impact and multifactorial etiology, encompassing genetic, hormonal, and environmental factors. Management strategies include sun protection and targeted treatments like glycolic acid peels and the modified Kligman's regimen to mitigate hyperpigmentation. Objective: To compare the clinical outcome specifically in terms of MASI score in epidermal melasma patients treated with the Modified Kligman's regimen alone versus combined with 35% Glycolic acid peels. Methods: In this randomized controlled trial, a total of 90 patients of epidermal melasma (with MASI score over 10) aged 18-55 years, visiting out-patient Dermatology department of Sheikh Zayed Hospital, Rahim Yar Khan were enrolled via non-probability consecutive sampling. The patients were divided into two groups (group A and group B), each having 45 patients. Patients in group A received the Modified Kligman's regimen (hydroquinone 4%, 0.05% tretinoin, and fluocinolone acetonide 0.01%), and those in group B received serial 35% Glycolic acid peels plus Modified Kligman's regimen over 3 months. Outcomes were measured at 4, 8, and 12-weeks post-treatment in terms of the MASI score. Results: Most of the patients i: e.75.5 % in group B showed moderate clinical improvement while most of the patients in group A i: e. 53.3% observed only mild improvement. In terms of the mean MASI score improvement, the Group B patients exhibited a significantly greater reduction from baseline compared to the Group A (8.91±2.42 vs. 7.05±4.05, p=0.010). Conclusions: The combination of Glycolic acid peels plus Modified Kligman's regimen is relatively more efficacious as compared to Modified Kligman's regimen alone.
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