Therapeutic Potential of Silodosin for Chronic Prostatitis: Efficacy and Safety Insights

Therapeutic Potential of Silodosin for Chronic Prostatitis

Authors

  • Abdul Basit Niazi Department of Urology, Niazi Medical and Dental College, Sargodha, Pakistan
  • Muhammad Asif Department of Urology, King Edward Medical University, Lahore, Pakistan
  • Irfan Ahmad Department of Nephrology, Akhtar Saeed Medical and Dental College, Lahore, Pakistan
  • Wajid Abdullah Department of Nephrology, Niazi Medical and Dental College, Sargodha, Pakistan
  • Sana Ashraf Department of Pediatrics, Tehsil Headquarter Hospital Raiwind, Lahore, Pakistan
  • Sadia Ghaffar Department of Obstetrics and Gynecology, Fatima Memorial Medical and Dental College, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i07.1883

Keywords:

Silodosin, Clinical Efficacy, Chronic Prostatitis, Safety

Abstract

Chronic prostatitis is a common urological condition impacting men globally and poses a considerable clinical challenge due to its diverse symptoms and vague causes. The symptoms significantly affect patients' quality of life. Objective: To investigate the efficacy and safety of silodosin in men with chronic prostatitis who have not previously been treated with alpha-blockers for this condition. Methods: A quasi-experimental study was conducted from July 2022 to June 2023 at Niazi Welfare Foundation Teaching Hospital, Sargodha. Eighty-two patients with chronic prostatitis were treated with 4 mg of silodosin once daily and monitored for 12 weeks. Data collection commenced following IRB approval (NM&DC-IRB-43) and informed consent from all participants. Descriptive statistics were used to calculate the mean and standard deviation. Mean differences in NIH-CPSI score were computed through paired t-test at p-value < 0.05, using SPSS version 25.0. Results: Results show noticeable improvement in CP and NIH-CPSI scores following treatment. The change in symptoms of CP and NIH-CPSI score before and after silodosin indication were statistically significant (p < 0.05). Additionally, the treatment was well-tolerated, with minimum adverse events reported. Conclusions: Silodosin, a novel selective inhibitor of the α1A-adrenergic receptor, proved to be effective in treating chronic prostatitis without significant side effects.

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Published

2024-07-31
CITATION
DOI: 10.54393/pjhs.v5i07.1883
Published: 2024-07-31

How to Cite

Niazi, A. B., Asif, M., Ahmad, I., Abdullah, W., Ashraf, S., & Ghaffar, S. (2024). Therapeutic Potential of Silodosin for Chronic Prostatitis: Efficacy and Safety Insights: Therapeutic Potential of Silodosin for Chronic Prostatitis. Pakistan Journal of Health Sciences, 5(07), 147–151. https://doi.org/10.54393/pjhs.v5i07.1883

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