Prevalence of Impaired Glucose Tolerance/Prediabetes in Local Adult Obese Population Presenting to A Tertiary Care Hospital

IGT in Local Adult Obese Population

Authors

  • Niktash Khan Hadi Department of Medicine, Hayatabad Medical Complex (HMC), Peshawar, Pakistan
  • Muhammad Salman Aamir Department of Endocrinology, Diabetes and Metabolic Diseases, Hayatabad Medical Complex, Peshawar, Pakistan
  • Tahir Ghaffar Department of Endocrinology, Diabetes and Metabolic Diseases, Hayatabad Medical Complex, Peshawar, Pakistan
  • Sulaiman Khan Department of Medicine, Hayatabad Medical Complex (HMC), Peshawar, Pakistan
  • Siraj ul Islam Department of Medicine, Hayatabad Medical Complex (HMC), Peshawar, Pakistan
  • Shafiullah Khan Devision Headquarter Hospital (DHQ), Kohat, Pakistan
  • Nizamuddin . Department of Endocrinology, Diabetes and Metabolic Diseases, Hayatabad Medical Complex, Peshawar, Pakistan
  • Muhammad Ali Department of Medicine, Hayatabad Medical Complex (HMC), Peshawar, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v4i01.486

Keywords:

Impaired Glucose Tolerance, Obesity, Prevalence

Abstract

Obesity is affecting all countries across the globe and becoming an epidemic. It is a major factor contributing to metabolic disorders, diabetes and cardiovascular diseases (CVD). In Pakistan, CVD has highest mortalities which is closely related to obesity and diabetes. Objective: To determine the frequency of impaired glucose tolerance (IGT) in local adult obese population. A cross sectional, descriptive study was designed department of Medicine, Hayatabad Medical Complex, Peshawar. Methods: A total of 136 patients with BMI of more than 25kg/m2 in Medical OPD with age between 18-60 years were included. Weight and height were measured for obesity and BMI calculation. All patients were subjected to 75gm oral glucose tolerance test after 08 hours overnight fast. Venous blood was withdrawn before and after the oral glucose solution and IGT were considered positive if the blood glucose level is between 140- 199mg/dl at 2-hour post oral glucose solution. Results: 136 patients were analyzed in which 42(31%) patients were having age between 18-40 years, 94(69%) patients were having age between 41-60 years. Mean age was 53 years with SD ± 10.44. Forty-nine (36%) patients were male and 87(64%) patients were female. Moreover 24(20%) patients had IGT while 112(80%) patients had normal glucose tolerance. Conclusion: Impaired glucose tolerance was found in 20% of adult obese population. The exponential rise from obesity 1 patients having 8% and obesity 3 patients having 57% IGT shows significantly increased risk.

References

Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012 Feb; 307(5): 491-7. doi: 10.1001/jama.2012.39.

World Health Organization (WHO). Global status report on noncommunicable diseases 2014. 2014. [Last cited: 11th Jan 2023]. Available at: https://apps.who.int/iris/bitstream/handle/10665/148114/WHO?sequence=6.

Basit A, Fawwad A, Qureshi H, Shera AS. Prevalence of diabetes, pre-diabetes and associated risk factors: second National Diabetes Survey of Pakistan (NDSP), 2016–2017. BMJ Open. 2018 Aug; 8(8): e020961. doi: 10.1136/bmjopen-2017-020961.

Misra A, Basit A, Vikram NK, Sharma R. High prevalence of obesity and associated risk factors in urban children in India and Pakistan highlights immediate need to initiate primary prevention program for diabetes and coronary heart disease in schools. Diabetes Research and Clinical Practice. 2006 Jan; 71(1): 101-2. doi: 10.1016/j.diabres.2005.06.006.

Aamir AH, Ul-Haq Z, Mahar SA, Qureshi FM, Ahmad I, Jawa A, et al. Diabetes Prevalence Survey of Pakistan (DPS-PAK): prevalence of type 2 diabetes mellitus and prediabetes using HbA1c: a population-based survey from Pakistan. BMJ Open. 2019 Feb; 9(2): e025300. doi: 10.1136/bmjopen-2018-025300.

World Health Organization. Western Pacific Region, International Association for the Study of Obesity. The Asia-Pacific Perspective. Redefining obesity and its treatment. 2000. [Last cited: 2nd Jun 2021]. Available at: www.diabetes.com.au/pdf/obesity_report.

Bahadur S, Yousaf M, Ayaz HM, Sohail Z. Self-reporting of obesity, overweight and health risks among 1st year MBBS students of Rehman medical college, Peshawar. Khyber Medical University Journal. 2013 Jun; 5(2): 98-102.

Samir N, Mahmud S, Khuwaja AK. Prevalence of physical inactivity and barriers to physical activity among obese attendants at a community health-care center in Karachi, Pakistan. BMC Research Notes. 2011 Dec; 4(1): 1-7. doi: 10.1186/1756-0500-4-174.

Hennild DE, Bjerregaard-Andersen M, Joaquím LC, Christensen K, Sodemann M, Beck-Nielsen H, et al. Prevalence of impaired glucose tolerance and other types of dysglycaemia among young twins and singletons in Guinea-Bissau. BMC Endocrine Disorders. 2016 Dec; 16(1): 1-0. doi: 10.1186/s12902-016-0126-6.

Derosa G, Cicero AF, D'Angelo A, Borghi C, Maffioli P. Effects of n‐3 pufas on fasting plasma glucose and insulin resistance in patients with impaired fasting glucose or impaired glucose tolerance. Biofactors. 2016 May; 42(3): 316-22.

Oh TJ, Min SH, Ahn CH, Kim EK, Kwak SH, Jung HS, et al. Response: Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance. Diabetes & Metabolism Journal. 2015 Jun; 39(3): 270-1. doi: 10.4093/dmj.2015.39.3.270.

Morandi A, Maschio M, Marigliano M, Miraglia Del Giudice E, Moro B, Peverelli P, et al. Screening for impaired glucose tolerance in obese children and adolescents: a validation and implementation study. Pediatric Obesity. 2014 Feb; 9(1): 17-25. doi: 10.1111/j.2047-6310.2012.00136. x.

Kalra S. Diabesity. Journal of Pakistan Medical Association. 2013 Apr; 63(4): 532-4.

Pi‐Sunyer FX. The obesity epidemic: pathophysiology and consequences of obesity. Obesity Research. 2002 Dec; 10(S12): 97S-104S. doi: 10.1038/oby.2002.202.

Ghergherechi R and Tabrizi A. Prevalence of impaired glucose tolerance and insulin resistance among obese children and adolescents. Therapeutics and Clinical Risk Managment. 2010 Jul; 6: 345-9. doi: 10.2147/tcrm.s12033.

Sartayeva A, Danyarova L, Begalina D, Nurgalieva Z, Baikadamova L, Adilova G. Gestational Diabetes: Prevalence and Risks for The Mother and Child. Georgian Medical News. 2022 Jul: 328: 47-52.

Ahmad MS, Iqtadar S, Mumtaz SU, Niaz Z, Waheed I, Abaidullah S. Frequency of impaired glucose tolerance in obese patients. Annals of King Edward Medical University. 2017 Oct; 23(4): 546-9. doi: 10.21649/akemu.v23i4.2202.

Malone JI and Hansen BC. Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite? Pediatric Diabetes. 2019 Feb; 20(1): 5-9. doi: 10.1111/pedi.12787.

Saaristo TE, Barengo NC, Korpi-Hyövälti E, Oksa H, Puolijoki H, Saltevo JT, et al. High prevalence of obesity, central obesity and abnormal glucose tolerance in the middle-aged Finnish population. BMC Public Health. 2008 Dec; 8(1): 1-8. doi: 10.1186/1471-2458-8-423.

Tramunt B, Smati S, Grandgeorge N, Lenfant F, Arnal JF, Montagner A, et al. Sex differences in metabolic regulation and diabetes susceptibility. Diabetologia. 2020 Mar; 63(3): 453-61. doi: 10.1007/s00125-019-05040-3.

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Published

2023-01-31
CITATION
DOI: 10.54393/pjhs.v4i01.486
Published: 2023-01-31

How to Cite

Khan Hadi, N. ., Salman Aamir, M. ., Ghaffar, T. ., Khan, S. ., Islam, S. ul ., Khan, S. ., ., N., & Ali, M. . (2023). Prevalence of Impaired Glucose Tolerance/Prediabetes in Local Adult Obese Population Presenting to A Tertiary Care Hospital: IGT in Local Adult Obese Population . Pakistan Journal of Health Sciences, 4(01), 84–88. https://doi.org/10.54393/pjhs.v4i01.486

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